Safety and efficacy of therapy with botulinum toxin in obesity: a pilot study
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Botulin toxin (BTX) has been proposed as a potential obesity treatment.
In a pilot study, the short-term efficacy and safety of BTX was assessed in eight subjects (four men, four women; median age, 46 years; range, 35–57 years) with severe obesity (median body mass index [BMI], 47.1 kg/m2; range 38.2–56.7 kg/m2) and multiple dietary treatment failures. In a single endoscopic session, 500 UI of BTX-A was injected in the gastric antral region.
No clinically significant side effects were observed. In all patients, despite their not being on a specific diet, a reduction of body weight was observed at 1 month (median baseline weight, 124.4 kg vs 121.8 kg at 1 month; P < 0.05). Two treatment-unrelated dropouts were observed. At 4 months, three of the six patients had a further weight loss. The treatment effect was apparently independent of changes in hunger or satiety, or of changes in fasting and postprandial plasma ghrelin and serum leptin, thus suggesting a different pharmacological mechanism.
BTX-A treatment appears to be safe and well tolerated by obese patients, while its short-term efficacy varied widely.
- Jankovic, J, Brin, MF (1991) Therapeutic uses of botulin toxin. N Engl J Med 324: pp. 1186-94
- Friedenberg, F, Gollamudi, S, Parkman, HP (2004) The use of botulinum toxin for the treatment of gastrointestinal motility disorders. Dig Dis Sci 49: pp. 165-75 CrossRef
- American Academy of Neurology Therapeutics and Technology Assessment Subcommittee: the clinical usefulness of botulinum toxin A in treating neurological disorders. Neurology 1990;40:1332–4.
- Gui, D, De Gaetano, A, Spada, PL, Viggiano, A, Cassetta, E, Albanese, A (2000) Botulinum toxin injected in the gastric wall reduces body weight and food intake in rats. Aliment Pharmacol Ther 14: pp. 829-34 CrossRef
- Rollnik, JD, Meier, PN, Manns, MP, Goke, M (2003) Antral injections of botulinum A toxin for the treatment of obesity. Ann Intern Med 138: pp. 359-60
- Dhillo, WS, Bloom, SR (2004) Gastrointestinal hormones and regulation of food intake. Horm Metab Res 36: pp. 846-51 CrossRef
- Safety and efficacy of therapy with botulinum toxin in obesity: a pilot study
Journal of Gastroenterology
Volume 40, Issue 8 , pp 833-835
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- botulinum toxin
- Industry Sectors
- Author Affiliations
- A1. Divisions of Nutrition and Gastrointestinal Rehabilitation, IRCCS Istituto Auxologico Italiano, P.O. Box 1, I-28044, Piancavallo (Verbania), Italy