Effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis
- Shwu-Huey TsaiAffiliated withDivision of Gastroenterology, Taichung Veterans General HospitalCollege of Life Science, National Chung Hsing University
- , Chuan-Mu ChenAffiliated withCollege of Life Science, National Chung Hsing University
- , Chi-Sen ChangAffiliated withDivision of Gastroenterology, Taichung Veterans General HospitalDepartment of Internal Medicine, Chung Shan Medical University
- , Gran-Hum ChenAffiliated withDivision of Gastroenterology, Taichung Veterans General HospitalNational Young-Min Medical University
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The effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis was investigated.
Esophageal motility and 24-h intragastric acidity were assessed in endoscopy-proven reflux esophagitis patients with (n = 50) and without (n = 50) H. pylori infection.
Most of the patients had a mild degree of esophagitis. There was no difference in the age, sex, or body mass index (BMI) between patients with and without H. pylori infection. The 24-h intragastric pH monitoring showed less acidity in patients with H. pylori infection than in those without H. pylori infection (median pH, 1.6 ± 0.3 vs 1.4 ± 0.1, with vs without H. pylori infection; P < 0.01). No difference in the patterns of esophageal motility dysfunction was noted between these two groups of patients.
Patients with reflux esophagitis and H. pylori infection had less intragastric acidity than those without H. pylori infection. However, the extent of acid suppression was insufficient to protect the esophagus from acid injury. In addition, the degree of esophageal motility dysfunction was similar in both groups. Therefore, H. pylori infection may play no role in the pathogenesis of reflux esophagitis.
Key wordsHelicobacter pylori reflux esophagitis intragastric acidity esophageal motility
- Effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis
Journal of Gastroenterology
Volume 39, Issue 9 , pp 821-826
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Helicobacter pylori
- reflux esophagitis
- intragastric acidity
- esophageal motility
- Industry Sectors
- Author Affiliations
- A1. Division of Gastroenterology, Taichung Veterans General Hospital, 160, Sec. 3, Chung-Kang Rd., Taichung, Taiwan, 407, ROC
- A2. College of Life Science, National Chung Hsing University, Taichung, Taiwan ROC
- A3. Department of Internal Medicine, Chung Shan Medical University, Taichung, Taiwan ROC
- A4. National Young-Min Medical University, Taipei, Taiwan ROC