Journal of Gastroenterology

, Volume 39, Issue 6, pp 570–574

A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan

  • Motoyoshi Yano
  • Hisao Hayashi
  • Kentaro Yoshioka
  • Yutaka Kohgo
  • Hiroyuki Saito
  • Yoshiro Niitsu
  • Junji Kato
  • Shiro Iino
  • Hiroshi Yotsuyanagi
  • Yoshimasa Kobayashi
  • Kinya Kawamura
  • Shinichi Kakumu
  • Masahiko Kaito
  • Jiro Ikoma
  • Shinya Wakusawa
  • Takeshi Okanoue
  • Yoshio Sumida
  • Fumiaki Kimura
  • Eiji Kajiwara
  • Michio Sata
  • Kei Ogata
Article

DOI: 10.1007/s00535-003-1344-z

Cite this article as:
Yano, M., Hayashi, H., Yoshioka, K. et al. J Gastroenterol (2004) 39: 570. doi:10.1007/s00535-003-1344-z

Abstract

Background

Increasing evidence indicates that iron cytotoxicity plays an important role in the pathogenesis of chronic hepatitis C (CHC). However, the biochemical effects of iron reduction therapy on CHC remain to be confirmed in a controlled study. This study aimed to test whether iron removal by repeated phlebotomy improves serum alanine aminotransferase (ALT) levels in patients with CHC.

Methods

Patients were randomly assigned to an iron reduction therapy or control group. The patients in the treatment group received 3-month iron reduction therapy by biweekly phlebotomy, while the patients in the control group were followed up for 3 months with regular blood tests alone.

Results

Thirty-three patients completed the 3-month treatment, while 29 patients received the complete follow-up. The serum ALT levels were reduced from 118 ± 79 to 73 ± 39 IU/L in the treatment group, but did not change in the control group (106 ± 45 versus 107 ± 48 IU/L). Posttreatment enzyme activity was decreased significantly from the baseline. Furthermore, it was significantly lower than the 3-month control level. Although 5 patients withdrew from the study, none was affected by any side effects of repeated phlebotomy that required them to discontinue the treatment.

Conclusions

This short-term controlled trial demonstrated the biochemical efficacy and safety of iron reduction therapy for patients with CHC.

Key words

oxidative stress free radicals phlebotomy 

Copyright information

© Springer-Verlag Tokyo 2004

Authors and Affiliations

  • Motoyoshi Yano
    • 1
  • Hisao Hayashi
    • 9
  • Kentaro Yoshioka
    • 1
  • Yutaka Kohgo
    • 2
  • Hiroyuki Saito
    • 2
  • Yoshiro Niitsu
    • 3
  • Junji Kato
    • 3
  • Shiro Iino
    • 4
  • Hiroshi Yotsuyanagi
    • 5
  • Yoshimasa Kobayashi
    • 6
  • Kinya Kawamura
    • 6
  • Shinichi Kakumu
    • 7
  • Masahiko Kaito
    • 8
  • Jiro Ikoma
    • 8
  • Shinya Wakusawa
    • 9
  • Takeshi Okanoue
    • 10
  • Yoshio Sumida
    • 10
  • Fumiaki Kimura
    • 11
  • Eiji Kajiwara
    • 12
  • Michio Sata
    • 13
  • Kei Ogata
    • 13
  1. 1.Third Department of Internal MedicineNagoya University School of MedicineNagoyaJapan
  2. 2.Third Department of Internal MedicineAsahikawa Medical CollegeAsahikawaJapan
  3. 3.Fourth Department of Internal MedicineSapporo Medical University School of MedicineSapporoJapan
  4. 4.Department of MedicineSeizankai Kiyokawa HospitalTokyoJapan
  5. 5.Department of Gastroenterology-HepatologySt. Marianna Medical CollegeKawasakiJapan
  6. 6.Second Department of Internal MedicineHamamatsu University School of MedicineHamamatsuJapan
  7. 7.Division of Gastroenterology, Department of MedicineAichi Medical University School of MedicineAichiJapan
  8. 8.Third Department of Internal MedicineMie University School of MedicineTsuJapan
  9. 9.Department of Medicine, Faculty of Pharmaceutical SciencesHokuriku UniversityKanazawaJapan
  10. 10.Department of Gastroenterology and HepatologyKyoto Prefectural University of Medicine, Graduate School of MedicineKyotoJapan
  11. 11.Department of Internal MedicineTamano Municipal HospitalTamanoJapan
  12. 12.Department of GastroenterologyNippon Steel Yawata Memorial HospitalKitakyushuJapan
  13. 13.Second Department of Internal MedicineKurume University School of MedicineKurumeJapan