Novel interleukin 1β polymorphism increased the risk of gastric cancer in a Korean population
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In a case-control study, including 331 gastric cancer cases and 433 controls, we assessed the association between the three polymorphisms and the risk of gastric cancer. All genotyping was performed in duplicate. To assess the DNA-binding activity of IL-1B-1473 in vitro, we performed an electrophoretic mobility shift assay (EMSA).
When cases were divided according to the histologic type of the tumor, a significant difference in genotype frequencies for IL-1B-1473 was observed only between intestinal-type cases and controls (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.0–3.5 and OR 2.1 and 95% CI, 1.1–4.2 in the CG and GG genotypes, respectively). In the cases, there was a deviation from Hardy-Weinberg equilibrium in the IL-1B-511/-31 loci confined to the intestinal type, due to the excess of heterozygotes. The IL-1B-1473G allele showed decreased binding to nuclear extract, indicating a wearker promoter activity on EMSA.
We identified a novel single-nucleotide polymorphism, 1473C→G, in the IL-1B promoter that was significantly associated with gastric cancer among Koreans. Our results also suggest that the association between IL-1B polymorphism and an increased risk of gastric cancer may depend on the histologic type of gastric cancer.
- Novel interleukin 1β polymorphism increased the risk of gastric cancer in a Korean population
Journal of Gastroenterology
Volume 39, Issue 5 , pp 429-433
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- interleukin 1β
- gastric cancer
- histologic type
- Industry Sectors
- Author Affiliations
- A1. Department of Clinical Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, South Korea
- A2. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- A3. Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- A4. Department of General Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea