, Volume 39, Issue 3, pp 242-246

Association of the −173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis

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Background

Methods

Genotyping was carried out, with a tetra-primer polymerase chain reaction (PCR) method, for 659 DNA specimens from 438 healthy volunteers and 221 patients with UC. Genotype distribution between cases and controls and the association of patients’ genotypes with clinical parameters were statistically evaluated.

Results

No significant difference in genotype distribution was found between UC patients and healthy controls. However, when the relation of the C/C genotype to clinical parameters in UC patients was evaluated by Fisher’s exact test, it was found that the frequency of the C/C genotype was higher in patients with pancolitis type than in those with other types restricted to the distal or left-sided colon (odds ratio [OR], 10.781; 95% confidence interval [CI], 1.342–86.619; P = 0.0074).

Conclusions

These data suggest that the MIF −173 G/C polymorphism may be related to the extent of disease in UC in a Japanese population.