Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
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Aberrant methylation of the SOCS-1 CpG island was detected in 6 of the 74 (8%) colorectal cancer specimens. No corresponding normal colorectal tissues showed SOCS-1 methylation. We then analyzed the correlation between the clinicopathological features and SOCS-1 aberrant methylation and found that younger age was significantly related to SOCS-1 methylation (P = 0.048).
These findings suggested that SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to an early onset of colorectal cancer.
- Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
Journal of Gastroenterology
Volume 39, Issue 2 , pp 120-124
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- colorectal cancer
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