Journal of Gastroenterology

, Volume 38, Issue 12, pp 1162–1166

Increased expression of MUC1 in advanced pancreatic cancer

  • Yuji Hinoda
  • Yoshito Ikematsu
  • Michiko Horinochi
  • Shuji Sato
  • Kotaro Yamamoto
  • Tomoko Nakano
  • Mikiko Fukui
  • Yutaka Suehiro
  • Yuichiro Hamanaka
  • Yoshiro Nishikawa
  • Hideo Kida
  • Shinji Waki
  • Masaaki Oka
  • Kohzoh Imai
  • Suguru Yonezawa
Article

DOI: 10.1007/s00535-003-1224-6

Cite this article as:
Hinoda, Y., Ikematsu, Y., Horinochi, M. et al. J Gastroenterol (2003) 38: 1162. doi:10.1007/s00535-003-1224-6

Background

MUC1 is associated with tumor invasion and metastasis, and is expressed in pancreatic cancer with a high frequency. This study explored whether MUC1 expression affected the survival of patients with pancreatic cancer.

Methods

Tissue specimens obtained from 70 patients with invasive ductal carcinoma of the pancreas, in pTNM stage III or IV, were immunostained with the anti-MUC1 monoclonal antibody DF3. The results of immunostaining were determined to be positive when more than 50% of the total cancer cells were positively stained. Association of the expression of the DF3 epitope with clinicopathological parameters or patients’ survival was statistically evaluated.

Results

The incidence of positivity of MUC1 expression was 55.7% (39/70) and this incidence was significantly higher in pTNM stage IV than in stage III (odds ratio [OR], 4.015; 95% confidence interval [CI], 1.459–11.0541; P = 0.0076). As there was a clear difference in overall survival between pTNM stages III and IV (P = 0.0016), the effect of MUC1 expression on survival was separately evaluated in each stage. It was shown that the expression of MUC1 was associated with unfavorable overall survival in stage IV (P = 0.0197).

Conclusions

Our data suggest that the expression of MUC1 may be related to the progression of pancreatic cancer.

Key words

MUC1 pancreatic cancer invasive ductal carcinoma pTNM stage overall survival 

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Yuji Hinoda
    • 1
  • Yoshito Ikematsu
    • 2
  • Michiko Horinochi
    • 3
  • Shuji Sato
    • 4
  • Kotaro Yamamoto
    • 5
  • Tomoko Nakano
    • 6
  • Mikiko Fukui
    • 1
  • Yutaka Suehiro
    • 1
  • Yuichiro Hamanaka
    • 1
  • Yoshiro Nishikawa
    • 2
  • Hideo Kida
    • 2
  • Shinji Waki
    • 2
  • Masaaki Oka
    • 5
  • Kohzoh Imai
    • 4
  • Suguru Yonezawa
    • 3
  1. 1.Department of Clinical Laboratory ScienceUbeJapan
  2. 2.Department of SurgeryHamamatsu Medical CenterHamamatsuJapan
  3. 3.Second Department of PathologyKagoshima University School of MedicineKagoshimaJapan
  4. 4.First Department of Internal MedicineSapporo Medical UniversitySapporoJapan
  5. 5.Second Department of SurgeryYamaguchi University School of MedicineUbeJapan
  6. 6.Department of OtolaryngologyYamaguchi University School of MedicineUbeJapan