Increased expression of MUC1 in advanced pancreatic cancer
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Tissue specimens obtained from 70 patients with invasive ductal carcinoma of the pancreas, in pTNM stage III or IV, were immunostained with the anti-MUC1 monoclonal antibody DF3. The results of immunostaining were determined to be positive when more than 50% of the total cancer cells were positively stained. Association of the expression of the DF3 epitope with clinicopathological parameters or patients’ survival was statistically evaluated.
The incidence of positivity of MUC1 expression was 55.7% (39/70) and this incidence was significantly higher in pTNM stage IV than in stage III (odds ratio [OR], 4.015; 95% confidence interval [CI], 1.459–11.0541; P = 0.0076). As there was a clear difference in overall survival between pTNM stages III and IV (P = 0.0016), the effect of MUC1 expression on survival was separately evaluated in each stage. It was shown that the expression of MUC1 was associated with unfavorable overall survival in stage IV (P = 0.0197).
Our data suggest that the expression of MUC1 may be related to the progression of pancreatic cancer.
- Increased expression of MUC1 in advanced pancreatic cancer
Journal of Gastroenterology
Volume 38, Issue 12 , pp 1162-1166
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- pancreatic cancer
- invasive ductal carcinoma
- pTNM stage
- overall survival
- Industry Sectors
- Author Affiliations
- A1. Department of Clinical Laboratory Science, 1-1-1 Minami-Kogushi, Ube, 755-8505, Japan
- A2. Department of Surgery, Hamamatsu Medical Center, Hamamatsu, Japan
- A3. Second Department of Pathology, Kagoshima University School of Medicine, Kagoshima, Japan
- A4. First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
- A5. Second Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan
- A6. Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan