A new clinicopathological entity of IgG4-related autoimmune disease
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To investigate the pathophysiology of AIP, we immunohistochemically examined the pancreas and other organs in eight patients with AIP, and in controls, using anti-CD4-T and CD8-T cell subsets, as well as IgG4 antibodies.
In AIP patients, severe or moderate infiltration of IgG4-positive plasma cells associated with CD4- or CD8-positive T lymphocytes was detected in the peripancreatic tissue (6/6), bile duct (8/8), gallbladder (8/8), portal area of the liver (3/3), gastric mucosa (5/7), colonic mucosa (2/2), salivary glands (1/2), lymph nodes (6/6), and bone marrow (2/2), as well as in the pancreas (8/8). There were few IgG4-positive plasma cells at the same sites in controls.
These results suggest that AIP is not simply pancreatitis but that it is a pancreatic lesion involved in IgG4-related systemic disease with extensive organ involvement. We propose a new clinicopathological entity, of a systemic IgG4-related autoimmune disease in which AIP and its associated diseases might be involved.
- A new clinicopathological entity of IgG4-related autoimmune disease
Journal of Gastroenterology
Volume 38, Issue 10 , pp 982-984
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- autoimmune pancreatitis
- autoimmune disease
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- Author Affiliations
- A1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan
- A2. Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
- A3. Department of Pathology, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
- A4. Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan