Journal of Gastroenterology

, Volume 38, Issue 8, pp 776–780

Multiple esophagogastric granular cell tumors

  • Hiroshi Maekawa
  • Takeo Maekawa
  • Kiyotaka Yabuki
  • Kouichi Sato
  • Yoshihisa Tamazaki
  • Keizou Kudo
  • Ryo Wada
  • Michio Matsumoto
Case report

DOI: 10.1007/s00535-002-1145-9

Cite this article as:
Maekawa, H., Maekawa, T., Yabuki, K. et al. J Gastroenterol (2003) 38: 776. doi:10.1007/s00535-002-1145-9

Multiple granular cell tumors of the esophagus and the stomach found in a 53-year-old man are reported. One lesion was detected within the lower thoracic esophagus and seven lesions were detected in the stomach. The esophageal tumor was resected endoscopically, and gastrectomy was performed for the multiple gastric lesions. Histologically, the tumors consisted of spindle or polyhedral cells and the cytoplasm contained punctated eosinophilic granules with positive immunohistochemical staining for S-100 protein. The tumors were mainly located in the submucosal layer. Some tumor cells were seen in the mucosae propria and the muscularis propria. The tumor cells were only slightly positive for p53- and Ki-67-immunohistochemical stainings. Based on these findings, we diagnosed the granular cell tumors as benign. Granular cell tumor is comparatively rare in clinical practice, but a few such tumors have been seen in the digestive tract. A few cases of multiple esophagogastric granular cell tumors have also been reported in the literature.

Key words

granular cell tumor esophagus stomach 

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Hiroshi Maekawa
    • 1
  • Takeo Maekawa
    • 1
  • Kiyotaka Yabuki
    • 1
  • Kouichi Sato
    • 1
  • Yoshihisa Tamazaki
    • 1
  • Keizou Kudo
    • 1
  • Ryo Wada
    • 2
  • Michio Matsumoto
    • 2
  1. 1.Department of Surgery, Izunagaoka HospitalJuntendo UniversityShizuokaJapan
  2. 2.Department of Pathology, Izunagaoka HospitalJuntendo UniversityShizuokaJapan

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