Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 13, Issue 4, pp 265–273

DNA methylation and hepatocellular carcinoma

  • Jingde Zhu
Topics: Role of epigenetic alterations in hepato-biliary and pancreatic cancer

DOI: 10.1007/s00534-005-1054-4

Cite this article as:
Zhu, J. J Hepatobiliary Pancreat Surg (2006) 13: 265. doi:10.1007/s00534-005-1054-4

Abstract

The epigenetic makeup of organisms forms a link between the genetic information (DNA sequence) and the gene expression (and therefore phenotype). It dictates the memory for the gene expression pattern that, in turn, specifies cell identity. DNA methylation is the most studied epigenetic mechanism, aberration of which prevails in cancer, resulting in an altered pattern of gene expression and, therefore, cancerous features, including genetic abnormalities: mutations and genome instability. Altered methylation in cancer occurs in two directions. A marked reduction in the overall level of DNA methylation has been linked to the activation of transcription/transposition and the overexpression of protooncogenes. In parallel, there is a common occurrence of a hypermethylated status of the promoter cytosine (CpG) island in genes involved in the negative control of cell growth and in the maintenance of genomic stability; therefore causing transcription silencing. It is thus necessary and important to establish a comprehensive profile of DNA methylation changes in the promoter CpG island in many genes, both for better understanding of the underlying mechanisms and for diagnostic purposes in cancer clinics. Hepatocellular carcinoma is one of the most threatening malignancies in East Asia and Africa. In this short review, I briefly outline our current understanding of DNA methylation in cancer in general, emphasizing its recent progress in hepatocellular carcinoma.

Key words

Epigenetics DNA methylation Hepatocellular carcinoma Diagnosis 

Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Jingde Zhu
    • 1
    • 2
  1. 1.Cancer Epigenetics and Gene Therapy Group, The State-Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer InstituteShanghai Jiaotong UniversityShanghaiChina
  2. 2.The College of Life SciencesZhejiang Science and Technology University, Xiasha University DistrictHangzhouChina