Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 12, Issue 6, pp 463–466

Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms

Authors

  • Tamotsu Kuroki
    • Department of Transplantation and Digestive SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Yoshitsugu Tajima
    • Department of Transplantation and Digestive SurgeryNagasaki University Graduate School of Biomedical Sciences
  • Takashi Kanematsu
    • Department of Transplantation and Digestive SurgeryNagasaki University Graduate School of Biomedical Sciences
Review article

DOI: 10.1007/s00534-005-1004-1

Cite this article as:
Kuroki, T., Tajima, Y. & Kanematsu, T. J Hepatobiliary Pancreat Surg (2005) 12: 463. doi:10.1007/s00534-005-1004-1

Abstract

Hepatolithiasis is more frequently seen in East Asian countries than in Western countries, and it is well known to represent a high-risk state for intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma is an aggressive tumor that shows a dismal outcome even after resection. Cancer results from multistep carcinogenesis; however, the precise molecular mechanisms involved in the genetic alterations in cancer remain unknown. The accumulation of alterations in cancer-related genes leads to disruptions in cell-cycle regulation and also to continuous cell proliferation. The present review provides an overview of cancer-related genes in intrahepatic cholangiocarcinogenesis arising in hepatolithiasis. Further study of molecular mechanisms in hepatolithiasis-related intrahepatic cholangiocarcinoma, and the delineation of the influence of the genes involved should lead to our understanding of cholangiocarcinogenesis.

Key words

HepatolithiasisIntrahepatic cholangiocarcinomaMolecular mechanism

Copyright information

© Springer-Verlag Tokyo 2005