Journal of Hepato-Biliary-Pancreatic Surgery

, Volume 10, Issue 3, pp 195–199

Ischemia-reperfusion injury of the human liver during hepatic resection

  • Yang-Il Kim

DOI: 10.1007/s00534-002-0730-x

Cite this article as:
Kim, YI. J Hepatobiliary Pancreat Surg (2003) 10: 195. doi:10.1007/s00534-002-0730-x


Haemorrhage during resection of the liver remains a significant threat to clinical outcome. Portal triad occlusion, with complete clamping of the hepatic inflow at the hepatoduodenal ligament, is a well-documented, safe, and useful means of alleviating this problem. Although this technique is effective in limiting blood loss, there is still controversy concerning the potential drawbacks of ischemia and subsequent reperfusion injury of the liver. This article highlights recent advances in our understanding of the clinical factors influencing ischemia-reperfusion injury of the liver, particularly in human patients. These factors include the cell components involved, the mechanisms that enable the human liver to tolerate long-term inflow occlusion, factors affecting clinical outcomes, and surgical and pharmacological techniques used to alleviate ischemia-reperfusion injury, including hypothermic hepatectomy.

Key words

Ischemia-reperfusion injury Human liver Portal triad occlusion 

Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • Yang-Il Kim
    • 1
  1. 1.Department of Surgery, Liver Research Institute, Biomolecular Engineering CenterKyungpook National University School of MedicineTaeguKorea

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