Supportive Care in Cancer

, Volume 9, Issue 3, pp 177–186

Determinants of the sensation of thirst in terminally ill cancer patients

  • Tatsuya Morita
  • Y. Tei
  • J. Tsunoda
  • S. Inoue
  • S. Chihara
Original article

DOI: 10.1007/s005200000205

Cite this article as:
Morita, T., Tei, Y., Tsunoda, J. et al. Support Care Cancer (2001) 9: 177. doi:10.1007/s005200000205

Abstract.

While a sensation of thirst causes severe distress for a certain proportion of cancer patients in the terminal stage, the factors contributing to this symptom have not been established. To clarify the association between sensation of thirst and medical factors, especially dehydration, a cross-sectional observational study was performed on terminally ill cancer patients receiving inpatient hospice care. On admission to a palliative care unit, 88 consecutive patients underwent blood sampling and were requested to rate the intensity of thirst on a visual analogue scale (VAS). Physicians prospectively evaluated factors that might potentially be contributing to the symptom. The mean VAS score for thirst was 5.0±2.8, and 18% of the patients complained of severe thirst with a VAS score of ≥8. No significant correlations were observed between the VAS score for thirst and the values of total protein, blood urea nitrogen (BUN), creatinine, sodium, osmolality, hematocrit, atrial natriuretic peptide (ANP), and biochemical dehydration defined by the levels of BUN, creatinine, sodium and osmolality. On the other hand, dehydration defined by ANP level (≤15 pg/ml), hyperosmolality (≥300 mosmol/kg), gastrointestinal cancer, survival, performance status, oral intake, vomiting, and stomatitis were significantly associated with the severity of thirst. In addition, mouth breathing and opioids were determined to be a potential clinical cause of severe thirst when a retrospective chart review was carried out. In conclusion, sensation of thirst is a frequent symptom in terminally ill cancer patients and is associated with dehydration, hyperosmolality, poor general conditions, stomatitis, oral breathing, and opioids. Careful assessments and treatment of underlying causes is important to alleviate patients' distress.

Palliative care Thirst Etiology Dehydration Neoplasms 

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Tatsuya Morita
    • 1
  • Y. Tei
    • 1
  • J. Tsunoda
    • 1
  • S. Inoue
    • 1
  • S. Chihara
    • 1
  1. 1.Seirei Hospice, Seirei Mikatabara Hospital, 3453 Mikatabara-cho, Hamamatsu, Shizuoka, 433–8558, JapanJapan