Supportive Care in Cancer

, Volume 9, Issue 2, pp 73–83

Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration

Authors

    • Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
  • Declan Walsh
    • Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
Review article

DOI: 10.1007/s005200000180

Cite this article as:
Davis, M. & Walsh, D. Support Care Cancer (2001) 9: 73. doi:10.1007/s005200000180

Abstract

Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions. Several guidelines of administration have been established. Physicians who are involved in pain management should have a fundamental understanding of methadone's unique properties.

Methadone N-methyl-d-asparate receptor Morphine Pharmacokinetics Pharmacodynamics
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Copyright information

© Springer-Verlag 2000