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Systematic review of the Multidimensional Fatigue Symptom Inventory-Short Form

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Abstract

Purpose

Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression. Fatigue may be experienced by individuals in different dimensions as physical, mental, and emotional tiredness. The purposes of this study were to review and characterize the use of the 30-item Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) in published studies and to evaluate the available evidence for its psychometric properties.

Methods

A systematic review was conducted to identify published articles reporting results for the MFSI-SF. Data were analyzed to characterize internal consistency reliability of multi-item MFSI-SF scales and test-retest reliability. Correlation coefficients were summarized to characterize concurrent, convergent, and divergent validity. Standardized effect sizes were calculated to characterize the discriminative validity of the MFSI-SF and its sensitivity to change.

Results

Seventy articles were identified. Sample sizes reported ranged from 10 to 529 and nearly half consisted exclusively of females. More than half the samples were composed of cancer patients; of those, 59 % were breast cancer patients. Mean alpha coefficients for MFSI-SF fatigue subscales ranged from 0.84 for physical fatigue to 0.93 for general fatigue. The MFSI-SF demonstrated moderate test-retest reliability in a small number of studies. Correlations with other fatigue and vitality measures were moderate to large in size and in the expected direction. The MFSI-SF fatigue subscales were positively correlated with measures of distress, depressive, and anxious symptoms. Effect sizes for discriminative validity ranged from medium to large, while effect sizes for sensitivity to change ranged from small to large.

Conclusions

Findings demonstrate the positive psychometric properties of the MFSI-SF, provide evidence for its usefulness in medically ill and nonmedically ill individuals, and support its use in future studies.

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References

  1. Neefjes ECW, van der Vorst MJDL, Blauwhoff-Buskermolen S, Verheul HMW (2013) Aiming for a better understanding and management of cancer-related fatigue. Oncologist 18:1135–1143

    Article  PubMed Central  PubMed  Google Scholar 

  2. de Raaf PJ, de Klerk C, van der Rijt CC (2013) Elucidating the behavior of physical fatigue and mental fatigue in cancer patients: a review of the literature. Psychooncology 22:1919–1929

    Article  PubMed  Google Scholar 

  3. Minton O, Stone P (2009) A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Ann Oncol 20:17–25

    Article  CAS  PubMed  Google Scholar 

  4. Whitehead L (2009) The measurement of fatigue in chronic illness: a systematic review of unidimensional and multidimensional fatigue measures. J Pain Symptom Manag 37:107–128

    Article  Google Scholar 

  5. Dittner AJ, Wessely SC, Brown RG (2004) The assessment of fatigue—a practical guide for clinicians and researchers. J Psychosom Res 56:157–170

    Article  CAS  PubMed  Google Scholar 

  6. Donovan KA, Jacobsen PB (2011) The Fatigue Symptom Inventory: a systematic review of its psychometric properties. Support Care Cancer 19:169–185

    Article  Google Scholar 

  7. Jean-Pierre P, Figueroa-Moseley CD, Kohli S et al (2007) Assessment of cancer-related fatigue: implications for clinical diagnosis and treatment. Oncologist 12:11–21

    Article  PubMed  Google Scholar 

  8. Jacobsen PB (2004) Assessment of fatigue in cancer patients. J Natl Cancer Inst Monogr 32:93–97

    Article  PubMed  Google Scholar 

  9. Stein KD, Martin SC, Hann DM, Jacobsen PB (1998) A multidimensional measure of fatigue for use with cancer patients. Cancer Pract 6:143–152

    Article  CAS  PubMed  Google Scholar 

  10. Stein KD, Jacobsen PB, Blanchard CM, Thors C (2004) Further validation of the multidimensional fatigue symptom inventory-short form. J Pain Symptom Manag 27:14–23

    Article  Google Scholar 

  11. Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum, Hillsdale

    Google Scholar 

  12. Husted JA, Cook RJ, Farewell VT, Gladman DD (2000) Methods for assessing responsiveness: a critical review and recommendations. J Clin Epidemiol 53:459–468

    Article  CAS  PubMed  Google Scholar 

  13. Prue G, Rankin J, Cramp F, Allen J, Gracey J (2006) Fatigue in gynaecological cancer patients: a pilot study. Support Care Cancer 14:78–83

    Article  CAS  PubMed  Google Scholar 

  14. Donnelly CM, Blaney JM, Lowe-Strong A et al (2011) A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors. Gynecol Oncol 122:618–624

    Article  CAS  PubMed  Google Scholar 

  15. Prue G, Allen J, Gracey J, Rankin J, Cramp F (2010) Fatigue in gynecological cancer patients during and after anticancer treatment. J Pain Symptom Manag 39:197–210

  16. Schmidt JE, Joyner MJ, Tonyan HM, Reid KI, Hooten WM (2012) Psychological and physiological correlates of a brief intervention to enhance self-regulation in patients with fibromyalgia. J Musculoskelet Pain 20:211–221

    Article  Google Scholar 

  17. Hawker GA, Gignac MAM, Badley E et al (2011) A longitudinal study to explain the pain-depression link in older adults with osteoarthritis. Arthritis Care Res 63:1382–1390

    Article  Google Scholar 

  18. Mead G, Lynch J, Greig C et al (2007) Evaluation of fatigue scales in stroke patients. Stroke 38:2090–2095

    Article  PubMed  Google Scholar 

  19. Bardwell WA, Burke SC, Thomas KS et al (2006) Fatigue varies by social class in African Americans but not Caucasian Americans. Int J Behav Med 13:252–258

    Article  PubMed  Google Scholar 

  20. Sadja J, Tomfohr L, Jimenez JA et al (2012) Higher physical fatigue predicts adherence to a 12-week exercise intervention in women with elevated blood pressure. Health Psychol 31:156–163

    Article  PubMed Central  PubMed  Google Scholar 

  21. Rodrigue JR, Mandelbrot DA, Hanto DW et al (2011) A cross-sectional study of fatigue and sleep quality before and after kidney transplantation. Clin Transpl 25:E13–E21

    Article  Google Scholar 

  22. Cordero ED, Loredo JS, Murray KE, Dimsdale JE (2012) Characterizing fatigue: the effects of ethnicity and acculturation. J Appl Biobehav Res 17:59–78

    Article  PubMed Central  PubMed  Google Scholar 

  23. Gramignano G, Lusso MR, Madeddu C et al (2006) Efficacy of L-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition 22:136–145

    Article  CAS  PubMed  Google Scholar 

  24. Lim WJ, Hong S, Nelesen R, Dimsdale JE (2005) The association fo obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects. Arch Intern Med 165:910–915

    Article  PubMed  Google Scholar 

  25. Rief W, Mills PJ, Ancoli-Israel S et al (2010) Overnight changes of immune parameters and catecholamines are associated with mood and stress. Psychosom Med 72:755–762

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Thomas KS, Bardwell WA, Ancoli-Israel S, Dimsdale JE (2006) The toll of ethnic discrimination on sleep architecture and fatigue. Health Psychol 25:635–642

    Article  PubMed  Google Scholar 

  27. Shochat T, Dagan E (2010) Sleep disturbances in asymptomatic BRCA1/2 mutation carriers: women at high risk for breast-ovarian cancer. J Sleep Res 19:333–340

    Article  PubMed  Google Scholar 

  28. Young KE, White CA (2006) The prevalence and moderators of fatigue in people who have been successfully treated for cancer. J Psychosom Res 60:29–38

    Article  PubMed  Google Scholar 

  29. Pien LC, Chu H, Chen WC et al (2011) Reliability and validity of a Chinese version of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF-C). J Clin Nurs 20:2224–2232

    Article  PubMed  Google Scholar 

  30. Krummenacher R, Lukas PS, Biasiutti FD et al (2009) Independent association of sleep quality, fatigue, and vital exhaustion with platelet count in patients with a previous venous thromboembolic event. Platelets 20:566–574

    Article  CAS  PubMed  Google Scholar 

  31. Lukas PS, Krummenacher R, Biasiutti FD et al (2009) Association of fatigue and psychological distress with quality of life in patients with a previous venous thromboembolic event. Thromb Haemost 102:1219–1226

    CAS  PubMed  Google Scholar 

  32. Dunn-Lewis C, Kraemer WJ, Kupchak BR et al (2011) A multi-nutrient supplement reduced markers of inflammation and improved physical performance in active individuals of middle to older age: a randomized, double-blind, placebo-controlled study. Nutr J 10:90–99

  33. Wilkinson DJ, Smeeton NJ, Castle PC, Watt PW (2011) Absence of neuropsychological impairment in hyperammonaemia in healthy young adults; possible synergism in development of hepatic encephalopathy (HE) symptoms? Metab Brain Dis 26:203–212

    Article  PubMed  Google Scholar 

  34. Calvio L, Feuerstein M, Hansen J, Luff GM (2009) Cognitive limitations in occupationally active malignant brain tumour survivors. Occup Med Oxford 59:406–412

    Article  Google Scholar 

  35. Redwine LS, Tsuang M, Rusiewicz A et al (2012) A pilot study exploring the effects of a 12-week T’ai Chi intervention on somatic symptoms of depression in patients with heart failure. J Altern Complement Med 18:744–748

    Article  PubMed Central  PubMed  Google Scholar 

  36. Roepke SK, Mausbach BT, von Känel R et al (2009) The moderating role of personal mastery on the relationship between caregiving status and multiple dimensions of fatigue. Int J Geriatr Psychiatry 24:1453–1462

    Article  PubMed Central  PubMed  Google Scholar 

  37. Lynch J, Mead G, Greig C et al (2007) Fatigue after stroke: the development and evaluation of a case definition. J Psychosom Res 63:539–544

    Article  PubMed  Google Scholar 

  38. Cormie P, Newton RU, Spry N et al (2013) Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases. Prostate Cancer Prostatic Dis 16:328–335

    Article  CAS  PubMed  Google Scholar 

  39. Banthia R, Malcarne VL, Roesch SC et al (2006) Correspondence between daily and weekly fatigue reports in breast cancer survivors. J Behav Med 29:269–279

    Article  PubMed  Google Scholar 

  40. Broeckel JA, Thors CL, Jacobsen PB, Small M, Cox CE (2002) Sexual functioning in long-term breast cancer survivors treated with adjuvant chemotherapy. Breast Cancer Res Treat 75:241–248

    Article  PubMed  Google Scholar 

  41. de Leeuw R, Studts JL, Carlson CR (2005) Fatigue and fatigue-related symptoms in an orofacial pain population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:168–174

    Article  PubMed  Google Scholar 

  42. Sobel-Fox RM, McSorley AM, Roesch SC et al (2013) Assessment of daily and weekly fatigue among African American cancer survivors. J Psychosoc Oncol 31:413–429

    Article  PubMed  Google Scholar 

  43. Clayton MF, Dudley WN, Musters A (2008) Communication with breast cancer survivors. Health Commun 23:207–221

    Article  PubMed  Google Scholar 

  44. Tomfohr LM, Ancoli-Israel S, Loredo JS, Dimsdale JE (2011) Effects of continuous positive airway pressure on fatigue and sleepiness in patients with obstructive sleep apnea: data from a randomized controlled trial. Sleep 34:121–126

    PubMed Central  PubMed  Google Scholar 

  45. Günaydin R, Karatepe AG, Çeşmeli N, Kaya T (2009) Fatigue in patients with ankylosing spondylitis: relationships with disease-specific variables, depression, and sleep disturbance. Clin Rheumatol 28:1045–1051

    Article  PubMed  Google Scholar 

  46. Bevans M, Wehrlen L, Prachenko O et al (2011) Distress screening in allogeneic hematopoietic stem cell (HSCT) caregivers and patients. Psychooncology 20:615–622

    Article  PubMed Central  PubMed  Google Scholar 

  47. Fagundes CP, Murray DM, Hwang BS et al (2011) Sympathetic and parasympathetic activity in cancer-related fatigue: more evidence for a physiological substrate in cancer survivors. Psychoneuroendocrinology 36:1137–1147

    Article  PubMed Central  PubMed  Google Scholar 

  48. Liu LQ, Fiorentino L, Natarajan L et al (2009) Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy. Psychooncology 18:187–194

    Article  PubMed Central  PubMed  Google Scholar 

  49. Taylor DL, Nichols JF, Pakiz B et al (2010) Relationships between cardiorespiratory fitness, physical activity, and psychosocial variables in overweight and obese breast cancer survivors. Int J Behav Med 17:264–270

    Article  PubMed Central  PubMed  Google Scholar 

  50. Banthia R, Malcarne VL, Ko CM, Varni JW, Sadler GR (2009) Fatigued breast cancer survivors: the role of sleep quality, depressed mood, stage and age. Psychol Health 24:965–980

    Article  PubMed  Google Scholar 

  51. Ancoli-Israel S, Liu LQ, Marler M et al (2006) Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Support Care Cancer 14:201–209

    Article  PubMed Central  PubMed  Google Scholar 

  52. Liu LQ, Rissling M, Natarajan L et al (2012) The longitudinal relationship between fatigue and sleep in breast cancer patients undergoing chemotherapy. Sleep 35:237–245

    PubMed Central  PubMed  Google Scholar 

  53. Ancoli-Israel S, Rissling M, Neikrug A et al (2012) Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer. Support Care Cancer 20:1211–1219

    Article  PubMed Central  PubMed  Google Scholar 

  54. Bower JE, Garet D, Sternlieb B et al (2012) Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial. Cancer 118:3766–3775

    Article  PubMed Central  PubMed  Google Scholar 

  55. Ritterband LM, Bailey ET, Thorndike FP et al (2012) Initial evaluation of an Internet intervention to improve the sleep of cancer survivors with insomnia. Psychooncology 21:695–705

    Article  PubMed Central  PubMed  Google Scholar 

  56. Thorndike FP, Ritterband LM, Gonder-Frederick LA et al (2013) A randomized controlled trial of an internet intervention for adults with insomnia: effects on comorbid psychological and fatigue symptoms. J Clin Psychol 69:1078–1093

    Article  PubMed Central  PubMed  Google Scholar 

  57. Mantovani G, Maccio A, Madeddu C et al (2010) Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia. J Mol Med JMM 88:85–92

    Article  CAS  Google Scholar 

  58. Mantovani G, Maccio A, Madeddu C et al (2010) Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer. Oncologist 15:200–211

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  59. Mantovani G, Madeddu C, Maccio A et al (2004) Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment. Cancer Epidemiol Biomark Prev 13:1651–1659

    CAS  Google Scholar 

  60. Mantovani G, Macciò A, Madeddu C et al (2008) Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Nutrition 24:305–313

    Article  CAS  PubMed  Google Scholar 

  61. Mantovani G, Maccio A, Madeddu C et al (2006) A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomark Prev 15:1030–1034

    Article  CAS  Google Scholar 

  62. Barton DL, Liu H, Dakhil SR et al (2013) Wisconsin ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst 105:1230–1238

    Article  PubMed Central  PubMed  Google Scholar 

  63. Liu LQ, Marler MR, Parker BA et al (2005) The relationship between fatigue and light exposure during chemotherapy. Support Care Cancer 13:1010–1017

    Article  PubMed Central  PubMed  Google Scholar 

  64. Liu LQ, Mills PJ, Rissling M et al (2012) Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy. Brain Behav Immun 26:706–713

    Article  PubMed Central  PubMed  Google Scholar 

  65. Mills PJ, Parker B, Dimsdale JE, Sadler GR, Ancoli-Israel S (2005) The relationship between fatigue and quality of life and inflammation during anthracycline-based chemotherapy in breast cancer. Biol Psychol 69:85–96

    Article  PubMed  Google Scholar 

  66. Janusek LW, Tell D, Albuquerque K, Mathews HL (2013) Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer. Brain Behav Immun 30(Suppl):S149–162

    Article  Google Scholar 

  67. Guillemin F, Bombardier C, Beaton D (1993) Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. J Clin Epidemiol 46:1417–1432

    Article  CAS  PubMed  Google Scholar 

  68. Helgeson VS, Tomich PL (2005) Surviving cancer: a comparison of 5-year disease-free breast cancer survivors with healthy women. Psychooncology 14:307–317

    Article  PubMed  Google Scholar 

  69. Siegel SD, Antoni MH, Fletcher MA et al (2006) Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup? J Psychosom Res 60:559–566

    Article  PubMed  Google Scholar 

  70. Balasubramaniam R, de Leeuw R, Zhu H et al (2007) Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: a blinded prospective comparison study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:204–216

    Article  PubMed  Google Scholar 

  71. Feuerstein M, Hansen JA, Calvio LC, Johnson L, Ronquillo JG (2007) Work productivity in brain tumor survivors. J Occup Environ Med 49:803–811

    Article  PubMed  Google Scholar 

  72. Collado-Hidalgo A, Bower JE, Ganz PA, Irwin MR, Cole SW (2008) Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings. Brain Behav Immun 22:1197–1200

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  73. Hansen JA, Feuerstein M, Calvio LC, Olsen CH (2008) Breast cancer survivors at work. J Occup Environ Med 50:777–784

    Article  PubMed  Google Scholar 

  74. Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP (2008) Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of “emotional allodynia”. Psychosom Med 70:338–344

    Article  PubMed Central  PubMed  Google Scholar 

  75. Schmidt JE, Carlson CR (2009) A controlled comparison of emotional reactivity and physiological response in masticatory muscle pain patients. J Orofac Pain 23:230–242

    PubMed  Google Scholar 

  76. Calvio L, Peugeot M, Bruns GL, Todd BL, Feuerstein M (2010) Measures of cognitive function and work in occupationally active breast cancer survivors. J Occup Environ Med 52:219–227

    Article  PubMed  Google Scholar 

  77. Lee I-S, Bardwell WA, Ancoli-Israel S, Dimsdale JE (2010) Number of lapses during the psychomotor vigilance task as an objective measure of fatigue. J Clin Sleep Med 6:163–168

    PubMed Central  PubMed  Google Scholar 

  78. Breckenridge LM, Bruns GL, Todd BL, Feuerstein M (2012) Cognitive limitations associated with tamoxifen and aromatase inhibitors in employed breast cancer survivors. Psychooncology 21:43–53

    Article  PubMed  Google Scholar 

  79. Fagundes CP, Lindgren ME, Shapiro CL, Kiecolt-Glaser JK (2012) Child maltreatment and breast cancer survivors: social support makes a difference for quality of life, fatigue and cancer stress. Eur J Cancer 48:728–736

    Article  PubMed Central  PubMed  Google Scholar 

  80. Aynehchi BB, Obourn C, Sundaram K, Bentsianov BL, Rosenfeld RM (2013) Validation of the Modified Brief Fatigue Inventory in head and neck cancer patients. Otolaryngol Head Neck Surg 148:69–74

    Article  PubMed  Google Scholar 

  81. Bennett JM, Glaser R, Andridge RR et al (2013) Long lasting effects of smoking: breast cancer survivors’ inflammatory responses to acute stress differ by smoking history. Psychoneuroendocrinology 38:179–187

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  82. Ganz PA, Kwan L, Castellon SA et al (2013) Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance. J Natl Cancer Inst 105:791–801

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  83. Gass JJ, Glaros AG (2013) Autonomic dysregulation in headache patients. Appl Psychophysiol Biofeedback 38:257–263

    Article  PubMed  Google Scholar 

  84. Moskowitz MC, Feuerstein M, Todd BL (2013) Job stress and physical activity related to elevated symptom clusters in breast cancer survivors at work. J Occup Environ Med 55:93–98

    Article  PubMed  Google Scholar 

  85. Stein KD, Denniston M, Baker F et al (2003) Validation of a modified Rotterdam Symptom Checklist for use with cancer patients in the United States. J Pain Symptom Manag 26:975–989

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The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Health Outcomes and Behavior Program, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-SCM, Tampa, FL, 33612, USA

    Kristine A. Donovan & Paul B. Jacobsen

  2. Behavioral Research Center, Intramural Research Department, American Cancer Society, Atlanta, GA, USA

    Kevin D. Stein & Corinne R. Leach

  3. Department of Behavioral Sciences and Health Education, Emory University Rollins School of Public Health, Atlanta, GA, USA

    Kevin D. Stein, Corinne R. Leach & Onaedo Ilozumba

  4. Department of Psychology, University of South Florida, Tampa, FL, USA

    Morgan Lee

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  1. Kristine A. Donovan
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  2. Kevin D. Stein
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  3. Morgan Lee
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  6. Paul B. Jacobsen
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Correspondence to Kristine A. Donovan.

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Donovan, K.A., Stein, K.D., Lee, M. et al. Systematic review of the Multidimensional Fatigue Symptom Inventory-Short Form. Support Care Cancer 23, 191–212 (2015). https://doi.org/10.1007/s00520-014-2389-7

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