Supportive Care in Cancer

, Volume 22, Issue 8, pp 2113–2118

Quality of life of chronic myeloid leukemia patients in Brazil: ability to work as a key factor

  • Nelson Hamerschlak
  • Carmino de Souza
  • Ana Lúcia Cornacchioni
  • Ricardo Pasquini
  • Daniel Tabak
  • Nelson Spector
  • Merula Steagall
Original Article

DOI: 10.1007/s00520-014-2196-1

Cite this article as:
Hamerschlak, N., de Souza, C., Cornacchioni, A.L. et al. Support Care Cancer (2014) 22: 2113. doi:10.1007/s00520-014-2196-1
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Abstract

Purpose

The purpose of this study was to evaluate the quality of life (QOL) of patients receiving treatment by the public health system in Brazil for chronic myeloid leukemia (CML), a disease requiring daily and strict compliance to oral medication and regular blood and bone marrow controls, which are invasive exams.

Methods

Between 2008 and 2010, patients with CML were surveyed by telephone. Quality of life was evaluated by the functional assessment of chronic illness therapy (FACIT) tool.

Results

The mean QOL among CML patients was 92.53 (out of 124 total points) in the trial outcome index, 78.50 (out of 108) in the general total score, and 130.43 (out of 176) in the leukemia total score. Patients who had the prescriptions recently changed anyway had better QOL general score (p = 0.012) and leukemia-specific score (p = 0.043) than those who remained with the same treatment. Imatinib was not associated with this change in QOL (p > 0.797). The more the patient felt able to work, the higher the scores in all three FACIT scales (p < 0.001, Spearman’s correlation). The use of imatinib (p = 0.012) was associated with a better ability to work, while chemotherapy (p = 0.017) and the use of hydroxyurea (p = 0.001) were inversely associated with work capability.

Conclusions

A recent change in medication can improve quality of life. The ability to work is an important component of quality of life of patients with CML. Ability to work should be specifically considered in CML treatment.

Keywords

Chronic-phase myeloid leukemiaPerceptionPatient complianceQuality of life

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Nelson Hamerschlak
    • 1
  • Carmino de Souza
    • 2
  • Ana Lúcia Cornacchioni
    • 3
  • Ricardo Pasquini
    • 4
  • Daniel Tabak
    • 5
  • Nelson Spector
    • 6
  • Merula Steagall
    • 7
  1. 1.Hospital Israelita Albert Einstein. Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  2. 2.Universidade Estadual de Campinas (Unicamp). Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  3. 3.Instituto da Criança. Hospital de Clínicas da Universidade de São Paulo (USP). Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  4. 4.Universidade Federal do Paraná. Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  5. 5.CENTRON-Centro de Tratamento Oncológico. Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  6. 6.Universidade Federal do Rio de Janeiro. Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil
  7. 7.Associação Brasileira de Linfoma e LeucemiaSão PauloBrazil