Original Article

Supportive Care in Cancer

, Volume 21, Issue 7, pp 2059-2066

First online:

Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study

  • J. S. GewandterAffiliated withDepartment of Radiation Oncology, University of Rochester Medical Center
  • , L. FanAffiliated withDepartment of Public Health, University of Rochester Medical Center
  • , A. MagnusonAffiliated withDepartment of Medicine, Hematology/Oncology, University of Rochester Medical Center
  • , K. MustianAffiliated withDepartment of Radiation Oncology, University of Rochester Medical Center
  • , L. PepponeAffiliated withDepartment of Radiation Oncology, University of Rochester Medical Center
  • , C. HecklerAffiliated withDepartment of Radiation Oncology, University of Rochester Medical Center
  • , J. HopkinsAffiliated withSoutheast Cancer Control Consortium, Piedmont HEM/ONC Assocs
  • , M. TejaniAffiliated withDepartment of Medicine, Hematology/Oncology, University of Rochester Medical Center
  • , G. R. MorrowAffiliated withDepartment of Radiation Oncology, University of Rochester Medical Center
    • , S. G. MohileAffiliated withDepartment of Medicine, Hematology/Oncology, University of Rochester Medical CenterWilmot Cancer Center Email author 

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Abstract

Purpose

This study was conducted in order to characterize the prevalence of falls and functional impairments (FIs) and their association with chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors.

Methods

We analyzed baseline assessments from a phase III RCT in cancer survivors with self-reported CIPN scores of >4 out of 10. Patients completed the EORTC QLQ-CIPN-20 for neuropathy and reported falls in the previous 3 months. FIs were defined using the Activities of Daily Living subsection of the Vulnerable Elder’s Scale. Associations of baseline characteristics and CIPN with falls and FIs were examined using logistic regression.

Results

Of 421 patients, 11.9 % experienced recent falls and 26.6 % reported FIs. Motor neuropathy was the only factor associated with falls (OR = 1.127, p = 0.01). Factors associated with FIs included non-white race (OR = 0.335 white relative to non-white, 0.781, p = 0.01) and greater motor neuropathy scores (OR = 1.262, p < 0.0001).

Conclusion

CIPN, primarily motor, is associated with falls and FIs. Future prospective research should investigate the ability of motor neuropathy severity to predict falls.

Keywords

Falls Functional impairments Neuropathy Cancer survivors