Supportive Care in Cancer

, Volume 20, Issue 11, pp 2795–2802

Frequency of depression among oncology outpatients and association with other symptoms

Authors

    • Department of Palliative Care and Rehabilitation Medicine, Unit 1414The University of Texas MD Anderson Cancer Center
    • Centre Hospitalier de Lyon-SudHospices Civils de Lyon
  • Elise Perceau
    • Centre Hospitalier de Lyon-SudHospices Civils de Lyon
  • Julien Berthiller
    • Pole Information Médicale Evaluation RechercheHospices Civils de Lyon
  • Pierre Saltel
    • Centre Léon Bérard
  • Veronique Trillet-Lenoir
    • Centre Hospitalier de Lyon-SudHospices Civils de Lyon
  • Olivier Tredan
    • Centre Léon Bérard
  • Jean-Pierre Coulon
    • Clinique Francois Chenieux
  • Eduardo Bruera
    • Department of Palliative Care and Rehabilitation Medicine, Unit 1414The University of Texas MD Anderson Cancer Center
  • Marilene Filbet
    • Centre Hospitalier de Lyon-SudHospices Civils de Lyon
Original Article

DOI: 10.1007/s00520-012-1401-3

Cite this article as:
Rhondali, W., Perceau, E., Berthiller, J. et al. Support Care Cancer (2012) 20: 2795. doi:10.1007/s00520-012-1401-3

Abstract

Purpose

Depression occurs among an estimated 15% of cancer patients (range, 1–77.5%). Our main objective was to identify the frequency of reported depression by using the Brief Edinburgh Depression Scale (BEDS) among cancer outpatients. Our secondary objective was to identify associated symptoms of cancer using the Edmonton Symptom Assessment System (ESAS) and to evaluate the screening performance of depression between ESAS and BEDS.

Methods

In this multicenter prospective study conducted, we used the ESAS to collect information on nine symptoms: pain, fatigue, nausea, depression, anxiety, drowsiness, shortness of breath, lack of appetite, and feeling of well-being (each rated from 0 to 10). The BEDS was used to assess for “probable depression” (score >6). Data were analyzed using a parametric and nonparametric test.

Results

A total of 146 patients completed the study. The prevalence of probable depression was 43/146 (29%). Probable depression was associated with increased fatigue (p = 0.008), depression (p < 0.0001), anxiety (p < 0.0001), shortness of breath (p = 0.01), and decreased feeling of well-being (p < 0.001). Among patients with probable depression, 42 (98%) patients were not using antidepressants. Regarding the sensitivity and the specificity, we determined that the optimal cutoff for using the ESAS as a depression screening tool was ≥2.

Conclusion

We found significant associations between probable depression as determined with the BEDS and five symptoms as detected with the ESAS. The vast majority of patients with probable depression were not receiving pharmacological treatment. Depression should be suspected in patients with higher symptom distress as for any one of these 5 ESAS items.

Keywords

DepressionCancerOutpatientScreening

Copyright information

© Springer-Verlag 2012