Supportive Care in Cancer

, 19:1909

Prevention of ovarian damage and infertility in young female cancer patients awaiting chemotherapy—clinical approach and unsolved issues

  • Katharina Hancke
  • Vladimir Isachenko
  • Evgenia Isachenko
  • Jürgen M. Weiss
Review Article

DOI: 10.1007/s00520-011-1261-2

Cite this article as:
Hancke, K., Isachenko, V., Isachenko, E. et al. Support Care Cancer (2011) 19: 1909. doi:10.1007/s00520-011-1261-2

Abstract

Great advances in the oncological therapy of childhood and adolescent cancer patients lead to an increase of young cancer survivors with a normal expectancy of life. The aggressive chemotherapy and/or radiation often compromises endocrine function with consecutive menopausal symptoms and sterility. Recently, new approaches were developed to preserve fertility with different methods to restore the ovarian function. The present review gives an overview of the current possibilities, which may be offered to these young cancer patients, as well as the chances of success and risks and the unsolved issues in special situations.

Keywords

ChemotherapyCryopreservationFertilityOvarian tissuePremature ovarian failureTransplantation

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Katharina Hancke
    • 1
  • Vladimir Isachenko
    • 1
  • Evgenia Isachenko
    • 1
  • Jürgen M. Weiss
    • 2
  1. 1.Department of Obstetrics and GynaecologyUniversity of UlmUlmGermany
  2. 2.Department of Obstetrics and GynaecologyUniversity of JenaJenaGermany