Supportive Care in Cancer

, Volume 20, Issue 4, pp 715–724

Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes

  • Jessica Frisk
  • Ann-Christine Källström
  • Najme Wall
  • Mats Fredrikson
  • Mats Hammar
Original Article

DOI: 10.1007/s00520-011-1134-8

Cite this article as:
Frisk, J., Källström, AC., Wall, N. et al. Support Care Cancer (2012) 20: 715. doi:10.1007/s00520-011-1134-8

Abstract

Purpose

Evaluate effects of electro-acupuncture (EA) and hormone therapy (HT) on health-related quality-of-life (HRQoL) and sleep in breast cancer survivors with vasomotor symptoms.

Methods

Forty-five women, randomized to EA (n = 27) for 12 weeks or HT (n = 18) for 24 months, were followed for up to 2 years. Distress caused by, and numbers of, hot flushes, hours slept and times woken up/night, Psychological and General Well-being Index (PGWB) and Women’s Health Questionnaire (WHQ) were registered before and during treatment and at 6, 9, 12, 18 and 24 months after start of treatment.

Results

After 12 weeks of EA (n = 19), WHQ improved from 0.32 (IQR 0.23–0.53) at baseline to 0.24 (IQR 0.12–0.39; p < 0.001) and PGWB from 78 (IQR 53–89) to 79 (IQR 68–93; p = 0.002). All sleep parameters improved and Hot Flush Score (HFS) decreased by 80%. At 12 months, WHQ, PGWB and all sleep parameters remained significantly improved (n = 14) and HFS decreased by 65%. After 12 weeks of HT (n = 18), WHQ improved from 0.29 (IQR 0.15–0.44) at baseline to 0.15 (IQR 0.05–0.22; p = 0.001), PGWB from 75 (IQR 59–88) to 90 (62–97; p = 0.102) and three of five sleep parameters improved.

Conclusion

Both EA and HT increased HRQoL and sleep, probably through decreasing numbers of and distress by hot flushes. Although flushes decreased less in the EA group than in the HT group, HRQoL improved at least to the same extent maybe due to other effects of EA, not induced by HT, e.g. on anxiety, vitality and sleep, supported by subscale analyses. EA should be further evaluated as treatment for women with breast cancer and climacteric complaints, since HT no longer can be recommended for these women.

Keywords

Acupuncture Breast neoplasm Hormone therapy Menopause Health-related quality-of-life 

Supplementary material

520_2011_1134_MOESM1_ESM.doc (39 kb)
AppendixSTRICTA items that replace CONSORT 2010 item 5 when reporting an acupuncture trial (DOC 39 kb)

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Jessica Frisk
    • 1
    • 2
    • 6
  • Ann-Christine Källström
    • 3
    • 6
  • Najme Wall
    • 4
  • Mats Fredrikson
    • 5
    • 6
  • Mats Hammar
    • 1
    • 6
  1. 1.Obstetrics and Gynaecology, Faculty of Health SciencesLinköping University, University HospitalLinköpingSweden
  2. 2.Clinical Department of SurgeryCounty Council of ÖstergötlandNorrkopingSweden
  3. 3.Clinical Department of Surgery, Division of OncologyHelsingborg HospitalHelsingborgSweden
  4. 4.Clinical Department of OncologyUniversity Hospital of LinköpingLinköpingSweden
  5. 5.Occupational and Environmental MedicineLinköping UniversityLinköpingSweden
  6. 6.Department of Clinical and Experimental Medicine, Faculty of Health SciencesLinköping UniversityLinköpingSweden

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