Original Article

Supportive Care in Cancer

, Volume 20, Issue 2, pp 367-373

First online:

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation

  • Haruhiko KashiwazakiAffiliated withGerodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine Email author 
  • , Takae MatsushitaAffiliated withGerodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • , Junichi SugitaAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
  • , Akio ShigematsuAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
  • , Kumiko KasashiAffiliated withDivision of Pharmacy, Hokkaido University Hospital
  • , Yutaka YamazakiAffiliated withOral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine
  • , Takashi KanehiraAffiliated withPreventive Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • , Satoshi YamamotoAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
  • , Takeshi KondoAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Tomoyuki EndoAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Junji TanakaAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Satoshi HashinoAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Mitsufumi NishioAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Masahiro ImamuraAffiliated withStem Cell Transplantation Center, Hokkaido University Hospital
    • , Yoshimasa KitagawaAffiliated withOral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine
    • , Nobuo InoueAffiliated withGerodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine

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Abstract

Goal of work

Little is known about the effects of professional oral health care (POHC) on the outcome of hematopoietic stem cell transplantation (HSCT). We evaluated the effects of POHC given by dentists and dental hygienists on the development of oral mucositis and febrile neutropenia (FN) after allogeneic bone marrow transplantation (BMT).

Patients and methods

We retrospectively studied 140 adult patients who had received allogeneic BMT, with or without POHC, in our hospital consecutively between February 2002 and December 2009. Oral mucositis was evaluated according to the World Health Organization scale.

Main results

The incidence of oral mucositis was 66.7% (52/78) in the patients who had received POHC, compared to 93.5% (58/62) in the non-POHC group (P < 0.001). The incidence of FN and the maximal level of CRP were also significantly lower in the POHC group. Multivariate analysis revealed that the POHC was significantly associated with the incidence of oral mucositis (odds ratio, 7.58; 95%CI, 2.45–23.34; P < 0.001).

Conclusions

We concluded that POHC reduced the incidences of oral mucositis and FN by upgrading the overall oral hygiene during HSCT.

Keywords

Professional oral health care Oral mucositis Bone marrow transplantation Multivariate analysis Quality of life