Supportive Care in Cancer

, Volume 19, Issue 7, pp 995–1000

Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation

  • Yoshihiko Soga
  • Yoshinobu Maeda
  • Fumihiko Ishimaru
  • Mitsune Tanimoto
  • Hiroshi Maeda
  • Fusanori Nishimura
  • Shogo Takashiba
Original Article

DOI: 10.1007/s00520-010-0923-9

Cite this article as:
Soga, Y., Maeda, Y., Ishimaru, F. et al. Support Care Cancer (2011) 19: 995. doi:10.1007/s00520-010-0923-9

Abstract

Purpose

Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT.

Methods

Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated.

Results

The changes in detection frequencies of CoNS and α-streptococci from before to 3 weeks after HCT were significant (P < 0.05, χ2 test): 14.5–53.3% and 92.7–53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P < 0.05, χ2 test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed.

Conclusion

Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.

Keywords

Bacterial substitutionOral mucosaHematopoietic cell transplantationCoagulase-negative StaphylococcusBacteremia

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Yoshihiko Soga
    • 1
  • Yoshinobu Maeda
    • 3
  • Fumihiko Ishimaru
    • 3
    • 4
  • Mitsune Tanimoto
    • 3
  • Hiroshi Maeda
    • 1
  • Fusanori Nishimura
    • 1
    • 2
  • Shogo Takashiba
    • 1
  1. 1.Department of Pathophysiology–Periodontal ScienceOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  2. 2.Department of Dental Science for Health Promotion, Division of Cervico-GnathostomatologyHiroshima University Graduate School of Biomedical SciencesHiroshimaJapan
  3. 3.Department of Hematology, Oncology and Respiratory MedicineOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayamaJapan
  4. 4.Okayama Red Cross Blood CenterOkayamaJapan