Evolving classification systems for cancer cachexia: ready for clinical practice?
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Involuntary weight loss, the defining factor of cachexia, is a common consequence of advanced cancer.
This review summarizes the actual cachexia definitions and classification systems (NCCTG-studies, Loprinzi et al.; PG-SGA, Ottery et al.; Cachexia Consensus Conference, Evans et al; Cancer Cachexia Study Group, Fearon et al.; and SCRINIO Working group, Bozzetti et al.). We describe the ongoing development of a new classification system for cancer cachexia, which is based on literature reviews and Delphi processes within the European Palliative Care Research Collaborative. The review describes the evolving understanding of the pathophysiological mechanisms of cachexia and outlines an overview on treatment options.
In this review an outlook on the requirements of a new decision guiding instrument is given and the challenges in clinical decision making in palliative are discussed.
- Evolving classification systems for cancer cachexia: ready for clinical practice?
Supportive Care in Cancer
Volume 18, Issue 3 , pp 273-279
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- Classification systems
- Cancer cachexia
- Industry Sectors
- Author Affiliations
- 1. Oncological Palliative Medicine, Division of Oncology/Hematology, Department of Internal Medicine and Palliative Care Center, Cantonal Hospital, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland
- 2. Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, Royal Infirmary, The University of Edinburgh, Edinburgh, UK
- 3. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
- 4. Department of Palliative Medicine, RWTH Aachen University, Aachen, Germany
- 5. Faculty of Medicine, Clinical Department of Cancer Research and Molecular Medicine, Trondheim, Norway