Unanticipated toxicities from anticancer therapies: Survivors’ perspectives
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Improved therapies in oncology have resulted in increased survival across numerous malignancies, shifting attention to other aspects of the cancer experience. In particular, the impact of treatment-related toxicities has gained considerable attention, due to their physical and psychosocial effects, and possible impact on clinical outcome. These untoward events have not been examined from the survivors' perspective.
To identify and describe treatment-related toxicities having a negative effect on quality of life from the perspective of cancer survivors.
Quantitative study using written questionnaires and content analysis.
Cancer survivors' workshop across the United States.
A total of 379 participants from six survivor groups: breast (n = 250), ovarian (n = 27), lung (n = 23), colorectal (n = 15), genitourinary (n = 23), and other cancers (n = 45).
Survivors' perceptions on treatment-related dermatologic, gastrointestinal, and constitutional toxicities.
Survivors reported an increased concern regarding dermatologic toxicities, including irritated and dry skin, after receiving their cancer treatment. These events had a negative effect on their lives. Although gastrointestinal and constitutional toxicities also had a negative effect, the concern over their development was unchanged prior to and after treatments.
The impact of dermatologic toxicities is unanticipated prior to cancer treatments. Since these events have a negative effect on survivors' lives, pretreatment counseling and effective interventions are vital in order to maximize quality of life and minimize unnecessary treatment interruptions or discontinuations.
- Jemal A, Thus MJ, Ries LA et al (2008) Annual report to the nation on the status of cancer, 1975–2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Ins 100(23):1672–1694 CrossRef
- Jemal A, Siegel R, Ward E et al (2009) Cancer statistics, 2009. CA Cancer J Clin 59(4):225–249 Epub 2009 May 27 CrossRef
- MMWR Morb Mortal Wkly Rep. (2004) 53(24):526–529
- Jemal A, Center MM, Ward E et al (2009) Cancer occurrence. Methods Mol Biol 471:3–29 CrossRef
- Boone SL, Rademaker A, Liu D et al (2007) Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results. Oncology 72:152–159 CrossRef
- Wildiers H (2007) Mastering chemotherapy dose reduction in elderly cancer patients. Eur J Cancer 43(15):2235–2241 CrossRef
- Frith H, Harcourt D, Fussell A (2007) Anticipating an altered appearance: women undergoing chemotherapy treatment for breast cancer. Eur J Oncol Nurs 11(5):385–391 CrossRef
- Aspinwall LG, Taylor SE (1997) A stitch in time: self-regulation and proactive coping. Psychol Bull 121(3):417–436 CrossRef
- Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70 CrossRef
- Bentzen SM, Trotti A (2007) Evaluation of early and late toxicities in chemoradiation trials. J Clin Oncol 25(26):4096–4103 CrossRef
- Loprinzi CL, Barton DL, Jatoi A et al (2007) Symptom control trials: a 20-year experience. J Support Oncol 5(3):119–125
- McCaughan E, Thompson K (2000) Informational needs of cancer patients receiving chemotherapy at a day-case unit in Northern Ireland. J Adv Nurs 6:851–858
- Montgomery N, Tomoyasu D, Bovbjerg M et al (1998) Patient's pre-treatment expectations of chemotherapy-related nausea are an independent predictor of anticipatory nausea. The Society of Behavioural Medicine 20((2):104–108 CrossRef
- Burish TG, Snyder SL, Jenkins RA (1991) Preparing patients for cancer chemotherapy: effect of coping preparation and relaxation interventions. J Consult Clin Psychol 59(4):518–525 CrossRef
- Lindley C, McCune JS, Thomason TE et al (1999) Perception of chemotherapy side effects: cancer versus noncancer patients. Cancer Pract 7(2):59–65 CrossRef
- Hackbarth M, Haas N, Fotopolou C et al (2008) Chemotherapy-induced dermatological toxicity: frequencies and impact on quality of life in women's cancer. Results of a prospective study. Support Care Cancer 16:267–273 CrossRef
- Fallowfield LJ (2008) Treatment decision-making in breast cancer: the patient–doctor relationship. Breast Cancer Res Treat 112:5–13 CrossRef
- Simminoff LA (1992) Improving communication with cancer patients. Oncology 6:83–87
- Butler L, Bacon M, Carey M et al (2004) Determining the relationship between toxicity and quality of life in an ovarian cancer chemotherapy clinical trial. J Clin Ocol 22:2461–2468 CrossRef
- McInnes DK, Cleary PD, Stein KD et al (2008) Perceptions of cancer-related information among cancer survivors: a report from the American Cancer Society's studies of cancer survivors. Cancer 113(6):1471–1479 CrossRef
- Richardson LC, Wang W, Hartzema AG et al (2007) The role of health related quality of life in early discontinuation of chemotherapy for breast cancer. Breast J 13(6):581–587 CrossRef
- Hall G, Phillips TJ (2005) Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol 53(4):555–568 CrossRef
- Fromme EK, Eilers KM, Mori M et al (2004) How accurate is clinician reporting of chemotherapy adverse events? A comparison with patient-reported symptoms from the quality-of-life questionnaire C30. J Clin Oncol 22(17):3485–3490 CrossRef
- Viele CS (2007) Managing oral chemotherapy: the healthcare practitioner's role. Am J Health Syst Pharm 64(9 Suppl 5):S25–S32 CrossRef
- Dodd MJ (1982) Assessing patient self-care for the side effects of cancer chemotherapy—part 1. Cancer Nurs 5(6):447–451 CrossRef
- Carelle N, Plotto E, Bellanger A et al (2002) Changing patient perceptions of the side effects of cancer chemotherapy. Cancer 95(1):155–163 CrossRef
- Unanticipated toxicities from anticancer therapies: Survivors’ perspectives
Supportive Care in Cancer
Volume 18, Issue 11 , pp 1461-1468
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Skin-related issues
- Hair loss
- Industry Sectors
- Author Affiliations
- 1. Department of Dermatology, Northwestern University’s Feinberg School of Medicine, 676 N. St. Clair St., Suite 1600, Chicago, IL, 60611, USA
- 2. University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
- 3. Washington University School of Medicine, St. Louis, MO, USA
- 4. SERIES Clinic, Robert H Lurie Comprehensive Cancer Center, Northwestern University’s Feinberg School of Medicine, 676 N. St. Clair, Suite 1600, Chicago, IL, 60611, USA