Supportive Care in Cancer

, Volume 18, Issue 7, pp 869–876

Insight in the prediction of chemotherapy-induced nausea

  • Joseph A. Roscoe
  • Gary R. Morrow
  • Ben Colagiuri
  • Charles E. Heckler
  • Bryan D. Pudlo
  • Lauren Colman
  • Karen Hoelzer
  • Andrew Jacobs
Original Article

DOI: 10.1007/s00520-009-0723-2

Cite this article as:
Roscoe, J.A., Morrow, G.R., Colagiuri, B. et al. Support Care Cancer (2010) 18: 869. doi:10.1007/s00520-009-0723-2

Abstract

Purpose

To identify risk factors for chemotherapy-related nausea.

Methods

We examined risk factors for nausea in 1,696 patients from three multicenter studies conducted from 1998 to 2004. All patients were beginning a chemotherapy regimen containing cisplatin, carboplatin, or doxorubicin. Nausea was assessed on a 1–7 scale four times a day for 4 days by diary.

Results

First, average nausea for breast cancer patients receiving doxorubicin (mean = 2.31) was significantly greater than for other patients receiving doxorubicin (mean = 1.82), patients receiving cisplatin (mean = 1.88), and patients receiving carboplatin (mean = 1.45), Ps < 0.01. Second, mean nausea decreased steadily with age, P < 0.0001. Third, patients rating themselves more susceptible to nausea had significantly more nausea (adjusted mean = 2.51) than patients rating themselves less susceptible (adjusted mean = 1.92) and were 2.8 times more likely to experience severe nausea, Ps < 0.0001. Fourth, expected nausea was a significant predictor of average nausea, P = 0.034, but not severe nausea, P = 0.31. Last, no evidence that gender is a significant predictor of nausea in 299 patients with gender neutral cancers, P = 0.35.

Conclusions

Specific patient characteristics, especially younger age and perceived susceptibility to nausea, can help clinicians in the early identification of patients who are more susceptible to treatment-related nausea.

Keywords

Chemotherapy Nausea Risk factor Doxorubicin Expectancy 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Joseph A. Roscoe
    • 1
    • 6
  • Gary R. Morrow
    • 1
  • Ben Colagiuri
    • 2
  • Charles E. Heckler
    • 1
  • Bryan D. Pudlo
    • 1
  • Lauren Colman
    • 3
  • Karen Hoelzer
    • 4
  • Andrew Jacobs
    • 5
  1. 1.University of Rochester Cancer Center Community Clinical Oncology Program Research Base, James P. Wilmot Cancer CenterUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Medical Psychology Research Unit, School of PsychologyUniversity of SydneySydneyAustralia
  3. 3.Northwest Community Clinical Oncology ProgramTacomaUSA
  4. 4.Central Illinois CCOP, Decatur Memorial HospitalDecaturUSA
  5. 5.Virginia Mason CCOPSeattleUSA
  6. 6.University of RochesterRochesterUSA

Personalised recommendations