Supportive Care in Cancer

, 17:1543

Reduction of chemotherapy-induced anorexia, nausea, and emesis through a structured nursing intervention: a cluster-randomized multicenter trial

  • Patrick Jahn
  • Petra Renz
  • Joerg Stukenkemper
  • Katrin Book
  • Oliver Kuss
  • Karin Jordan
  • Ingrid Horn
  • Anette Thoke-Colberg
  • Hans-Joachim Schmoll
  • Margarete Landenberger
Original Article

DOI: 10.1007/s00520-009-0698-z

Cite this article as:
Jahn, P., Renz, P., Stukenkemper, J. et al. Support Care Cancer (2009) 17: 1543. doi:10.1007/s00520-009-0698-z

Abstract

Objectives

The purpose of this present study was to evaluate Self-care Improvement through Oncology Nursing (SCION) program to reduce distressing anorexia, nausea, and emesis (ANE) in cancer patients undergoing chemotherapy.

Methods

Two hundred eight patients receiving chemotherapy with moderate to high emetogenic potential participated in a cluster randomized trial on 14 wards in two German university hospitals. Additionally to standard antiemetic treatment, patients from the intervention wards received the SCION program consisting of four modules: advisory consultation, optimizing emesis prophylaxis, nutrition counseling, and relaxation. Patients from the control group received standard antiemetic treatment and standard care. Primary outcome was the group difference in ANE intensity assessed by Common Terminology Criteria for adverse events (CTCAE).

Main results

The SCION program did not result in a significant difference in the incidence of ANE symptoms as compared to standard care: mean difference on CTCAE scale was 0.24 pts (95%CI, −1.17 to 1.66 pts; P = 0.733). No difference could be found regarding patients’ knowledge of side effects, self-care interventions, and agency. Health-related quality of life was significantly better for patients in the control group (mean difference 10.2 pts; 95%CI, 1.9 to 18.5; P = 0.017).

Conclusions

Contrary to our expectations, the groups did not differ in ANE intensity caused by the overall low acute or delayed symptom intensity. Symptom hierarchy in cancer patients alters and challenges nursing interventions targeting the patients’ self-care strategies.

Keywords

NauseaEmesisChemotherapySelf-careSymptom management

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Patrick Jahn
    • 1
  • Petra Renz
    • 1
  • Joerg Stukenkemper
    • 2
  • Katrin Book
    • 2
  • Oliver Kuss
    • 3
  • Karin Jordan
    • 4
  • Ingrid Horn
    • 4
  • Anette Thoke-Colberg
    • 2
  • Hans-Joachim Schmoll
    • 4
  • Margarete Landenberger
    • 1
  1. 1.Institute for Health and Nursing Science, Medical FacultyMartin-Luther-University Halle-WittenbergHalleGermany
  2. 2.University Hospital rechts der IsarMunich Technical UniversityMunichGermany
  3. 3.Institute for Medical Epidemiology, Biostatistics, and InformaticsMartin-Luther-University Halle-WittenbergHalle (Saale)Germany
  4. 4.University Clinic and Polyclinic for Internal Medicine IV, University Hospital HalleMartin-Luther-University Halle-WittenbergHalle (Saale)Germany