Original Article

Supportive Care in Cancer

, Volume 17, Issue 2, pp 181-189

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations

  • Floortje MolsAffiliated withCoRPS—Center of Research on Psychology in Somatic Diseases, Tilburg UniversityComprehensive Cancer Center South (CCCS), Eindhoven Cancer RegistryCoRPS, Department of Medical Psychology, Tilburg University Email author 
  • , Corina J. van den HurkAffiliated withComprehensive Cancer Center South (CCCS), Eindhoven Cancer RegistryDepartment of Clinical Oncology, Leiden University Medical Center
  • , Ad J. J. M. VingerhoetsAffiliated withClinical Psychology Section, Tilburg University
  • , Wim P. M. BreedAffiliated withComprehensive Cancer Center South (CCCS), Eindhoven Cancer Registry



The objective of this prospective multicenter study was to obtain insight into the severity and burden of hair loss among cancer patients treated with chemotherapy. In addition, we described the effectiveness and burden of scalp cooling and the satisfaction with wigs, with hair regrowth, and with body image.

Materials and methods

Breast cancer patients treated with (n = 98) and without (n = 168) scalp cooling completed questionnaires before chemotherapy and 3 weeks and 6 months after completion of chemotherapy.


Scalp cooling was effective in preventing chemotherapy-induced hair loss in 32 of 62 available patients (52%). Even though patients knew hair loss was temporary, it was a burden to 54% of them (n = 100). Scalp cooling was a burden for only 17 out of 51 patients (33%). Most patients who used a wig or head cover were satisfied with it (82%, n = 126). Patients were moderately satisfied with the regrowth of their hair after chemotherapy (mean 11.6; SD 2.53; range 0–20). Successfully cooled patients rated their hair as less important for their body image compared to patients who did experience hair loss (p = 0.014).


Chemotherapy-induced hair loss is perceived as burdensome. It may be prevented by offering scalp cooling which is often an effective method to prevent this form of hair loss and is tolerated well by patients. However, if possible, scalp-cooling techniques should be improved and their effectiveness should be increased because if scalp cooling is unsuccessful, patients’ rate their hair loss as more burdensome compared to noncooled patients.


Breast cancer Scalp cooling Hair loss Alopecia Chemotherapy Wig Body image