Supportive Care in Cancer

, Volume 16, Issue 8, pp 879–889

Impact of skeletal complications on patients’ quality of life, mobility, and functional independence

  • Luis Costa
  • Xavier Badia
  • Edward Chow
  • Allan Lipton
  • Andrew Wardley
Review Article

DOI: 10.1007/s00520-008-0418-0

Cite this article as:
Costa, L., Badia, X., Chow, E. et al. Support Care Cancer (2008) 16: 879. doi:10.1007/s00520-008-0418-0



Skeletal-related events (SREs) from malignant bone disease cause considerable morbidity and can dramatically reduce patients’ quality of life.


Pathologic fractures often require surgical intervention and palliative radiotherapy. Thus, patients suffer impaired mobility, loss of functional independence, and diminished health-related quality of life (HRQOL). Bisphosphonates can delay the onset and reduce the incidence of SREs and have become the standard of care for the treatment of malignant bone disease; however, minimal information on the effects of bisphosphonate treatment on HRQOL is available. Targeted HRQOL assessments for patients with malignant bone disease are currently under development and are discussed herein.


Bone metastases Bone pain Breast cancer Prostate cancer Zoledronic acid 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Luis Costa
    • 1
  • Xavier Badia
    • 2
  • Edward Chow
    • 3
  • Allan Lipton
    • 4
  • Andrew Wardley
    • 5
  1. 1.Instituto de Medicina Molecular-LisboaServico de Oncologia, Hospital de Santa MariaLisbonPortugal
  2. 2.Health Economics and Outcomes ResearchBarcelonaSpain
  3. 3.Radiation OncologyToronto-Sunnybrook Regional Cancer CentreTorontoCanada
  4. 4.Milton S. Hershey Medical CenterPennsylvania State UniversityHersheyUSA
  5. 5.Cancer Research Department of Medical OncologyChristie Hospital NHS Foundation TrustManchesterUK

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