, Volume 16, Issue 8, pp 879-889
Date: 08 Apr 2008

Impact of skeletal complications on patients’ quality of life, mobility, and functional independence

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Abstract

Introduction

Skeletal-related events (SREs) from malignant bone disease cause considerable morbidity and can dramatically reduce patients’ quality of life.

Discussion

Pathologic fractures often require surgical intervention and palliative radiotherapy. Thus, patients suffer impaired mobility, loss of functional independence, and diminished health-related quality of life (HRQOL). Bisphosphonates can delay the onset and reduce the incidence of SREs and have become the standard of care for the treatment of malignant bone disease; however, minimal information on the effects of bisphosphonate treatment on HRQOL is available. Targeted HRQOL assessments for patients with malignant bone disease are currently under development and are discussed herein.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00520-008-0496-z