Supportive Care in Cancer

, 15:1243

Effectiveness of bisphosphonates on bone pain and quality of life in breast cancer patients with metastatic bone disease: a review

Review Article

DOI: 10.1007/s00520-007-0244-9

Cite this article as:
Diel, I.J. Support Care Cancer (2007) 15: 1243. doi:10.1007/s00520-007-0244-9



Almost all patients with breast cancer and bone metastases suffer bone pain. Many receive bisphosphonate therapy only when the pain becomes unbearable or there is a direct threat of skeletal complications.


However, clinical trial data demonstrate that bisphosphonates offer significant and sustained relief from bone pain and can also improve quality of life in patients with metastatic breast cancer.


Moreover, new treatment schedules using high dose bisphosphonates can offer rapid relief of acute, severe bone pain.


Bisphosphonates Bone metastases Pain Quality of life Breast cancer 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Institute for Gynecological OncologyMannheimGermany
  2. 2.CGG-Klinik GmbHMannheimGermany