Supportive Care in Cancer

, Volume 14, Issue 6, pp 516–518

New thoughts on the pathobiology of regimen-related mucosal injury

  • Lowell Anthony
  • Joanne Bowen
  • Adam Garden
  • Ian Hewson
  • Stephen Sonis
Review Article

DOI: 10.1007/s00520-006-0058-1

Cite this article as:
Anthony, L., Bowen, J., Garden, A. et al. Support Care Cancer (2006) 14: 516. doi:10.1007/s00520-006-0058-1

Abstract

Background

Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient’s mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors.

Conclusion

Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.

Keywords

mucosal injurycancer theraphyradiationdrugsgenetic influences

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Lowell Anthony
    • 1
  • Joanne Bowen
    • 2
    • 3
  • Adam Garden
    • 4
  • Ian Hewson
    • 5
  • Stephen Sonis
    • 6
  1. 1.The Stanley S. Scott Cancer CenterLSUHSCNew OrleansUSA
  2. 2.Department of MedicineThe University of AdelaideAdelaideAustralia
  3. 3.Department of Medical OncologyThe Royal Adelaide HospitalAdelaideAustralia
  4. 4.MD Anderson Cancer CenterHoustonUSA
  5. 5.The Royal Melbourne HospitalVictoriaAustralia
  6. 6.Brigham and Women’s HospitalBostonUSA