Supportive Care in Cancer

, Volume 14, Issue 6, pp 558–565

Anti-inflammatory agents in the management of alimentary mucositis

  • Rajesh V. Lalla
  • Mark M. Schubert
  • Rene-Jean Bensadoun
  • Dorothy Keefe
Review Article

DOI: 10.1007/s00520-006-0050-9

Cite this article as:
Lalla, R.V., Schubert, M.M., Bensadoun, RJ. et al. Support Care Cancer (2006) 14: 558. doi:10.1007/s00520-006-0050-9



Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications.

Materials and methods

In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.


This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.


Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Rajesh V. Lalla
    • 1
  • Mark M. Schubert
    • 2
    • 3
  • Rene-Jean Bensadoun
    • 4
  • Dorothy Keefe
    • 5
  1. 1.Department of Oral Health and Diagnostic Sciences MC1605University of Connecticut Health CenterFarmingtonUSA
  2. 2.Department of Oral MedicineUniversity of WashingtonSeattleUSA
  3. 3.Oral MedicineSeattle Cancer Care AllianceSeattleUSA
  4. 4.Department of Radiation OncologyCentre Antoine-LacassagneNiceFrance
  5. 5.Department of MedicineUniversity of AdelaideAdelaideSouth Australia

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