Review Article

Supportive Care in Cancer

, Volume 14, Issue 6, pp 566-572

Amifostine in the management of radiation-induced and chemo-induced mucositis

  • Rene-Jean BensadounAffiliated withDepartment of Radiation Oncology, Centre Antoine-Lacassagne Email author 
  • , Mark M. SchubertAffiliated withDepartment of Oral Medicine, University of Washington, Oral Medicine Service, Seattle Cancer Care Alliance
  • , Rajesh V. LallaAffiliated withDepartment of Oral Health and Diagnostic Sciences MC1605, University of Connecticut Health Center
  • , Dorothy KeefeAffiliated withDepartment of Medicine, University of Adelaide

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Mucositis is a significant complication of cancer therapy, with important clinical and economic implications. In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) conducted an evidence-based update review of the literature on mucositis. The goal of this literature review is to update previously published guidelines for the management of mucositis.


This article reports the findings of the subgroup charged with reviewing the literature related to amifostine.


Amifostine Mucositis Radiotheraphy Chemotheraphy