Supportive Care in Cancer

, Volume 13, Issue 7, pp 554–558

The comparative effects of povidone-iodine and normal saline mouthwashes on oral mucositis in patients after high-dose chemotherapy and APBSCT—results of a randomized multicentre study


    • Department of Haemato-OncologyUniversity Hospital
  • Eva Bystřická
    • Department of Haemato-OncologyUniversity Hospital
  • Vladimír Koza
    • Department of Haemato-OncologyUniversity Hospital
  • Jana Sčudlová
    • Department of Haemato-OncologyUniversity Hospital Olomouc
  • Vladislava Pavlicová
    • Department of Clinical HaematologyUniversity Hospital
  • Dana Valentová
    • Department of Haematology and Transfusion MedicineUniversity Hospital
  • Jana Bocková
    • Department of HaematologyUniversity Hospital
  • Lubica Mišaniová
    • Department of HaematologyF.D.Roosevelt Hospital
Short Communication

DOI: 10.1007/s00520-005-0792-9

Cite this article as:
Vokurka, S., Bystřická, E., Koza, V. et al. Support Care Cancer (2005) 13: 554. doi:10.1007/s00520-005-0792-9


Antimicrobial solutions are widely used in the nursing care of chemotherapy induced oral mucositis (OM). There is little evidence, however, supporting their use for reducing mucosal damage. In our study, 132 patients were randomized to use normal saline (n=65) or povidone-iodine diluted 1:100 (n=67) mouthwashes for OM prophylaxis and treatment after high-dose chemotherapy comprising BEAM or HD-L-PAM followed by autologous peripheral stem cell transplantation. The study groups were well balanced in respect of age, sex, chemotherapy and the number of CD34+ cells in the graft. No significant difference was found between the groups in respect of OM characteristics, fever of unknown origin (FUO) and other infections. The antimicrobial solution was less tolerable for patients. OM occurred significantly more often in females than in males (86% vs 60%, P=0.0016) and was worse and of longer duration. The mechanical effect of mouthwashes might have a certain importance in FUO prevention. When indicating oral rinses, the patient’s individual preference and tolerance of solutions offered should be considered.


Oral mucositisPovidone-iodineMouthwashesAntimicrobial rinsesAutologous transplantationNursing

Copyright information

© Springer-Verlag 2005