Pediatric Nephrology

, Volume 12, Issue 3, pp 210–213

Urinary tract infections per se do not cause end-stage kidney disease

  • Sreedevi Sreenarasimhaiah
  • Stanley Hellerstein
Clinical nephrology

DOI: 10.1007/s004670050439

Cite this article as:
Sreenarasimhaiah, S. & Hellerstein, S. Pediatr Nephrol (1998) 12: 210. doi:10.1007/s004670050439


The objective of this study was to determine the frequency with which urinary tract infection (UTI) in the absence of concomitant underlying abnormalities caused end-stage renal disease (ESRD). The records of 102 patients with ESRD (disease necessitating dialysis and/or transplant) seen at Children’s Mercy Hospital during a 10-year period (1986 – 1995) were reviewed. Obstructive uropathy, aplastic/hypoplastic/dysplastic kidneys, polycystic kidney disease, congenital nephrotic syndrome, acquired glomerulonephritis, idiopathic interstitial nephritis, hemolytic uremic syndrome, and a variety of systemic conditions were the cause of ESRD in 99 children; 3 children had reflux nephropathy, 1 of whom had no history of a UTI and another who had a single, afebrile UTI. A girl with a history of recurrent UTIs since 4 years of age had an elevated serum creatinine and grade II – III bilateral vesicoureteric reflux when evaluated at 8 years of age. She had ureteral reimplantations and control of the infections, but progressed to ESRD. This child appears to be the only 1 of 102 children who developed ESRD because of acquired renal injury in which UTIs were an important contributing factor.

Key words: Urinary tract infectionsVesicoureteric refluxReflux nephropathyEnd-stage kidney disease

Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 1998

Authors and Affiliations

  • Sreedevi Sreenarasimhaiah
    • 1
  • Stanley Hellerstein
    • 1
  1. 1.Section of Nephrology, The Children’s Mercy Hospital, The University of Missouri School of Medicine, Kansas City, Missouri, USAUS