Pediatric Nephrology

, Volume 14, Issue 7, pp 598–601

Bone morphogenetic proteins and skeletal development: the kidney-bone connection

  • A. H. Reddi
Regulation of cartilage and bone growth / Review article

DOI: 10.1007/s004670000364

Cite this article as:
Reddi, A. Pediatr Nephrol (2000) 14: 598. doi:10.1007/s004670000364


The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens isolated and cloned from the demineralized extracellular matrix of bone. BMPs and related cartilage-derived morphogenetic proteins (CDMPs) initiate, promote and maintain bone and cartilage. The pleiotropic effects of BMPs are based on concentration-dependent thresholds. Targeted disruption of gene action by homologous recombination has demonstrated the role of BMP 7 in kidney, eye and skeletal development. BMP 7 is critical for kidney tubulogenesis, retinal pigmented epithelium differentiation and skeletal pattern. BMP 7 is also synthesized by the kidney and is detectable in serum; hence BMP 7 is both an autocrine and endocrine morphogen. It is likely renal BMP 7 may influence skeletal development and growth in children although there may be sources of other BMPs with skeletogenic actions. In conclusion, we are beginning to unravel the mysteries of kidney-bone connection with special reference to pediatric nephrology.

Key words MorphogensCytokinesCartilageBMP receptors

Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2000

Authors and Affiliations

  • A. H. Reddi
    • 1
  1. 1.Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, School of Medicine, Sacramento, CA 95817, USAUS
  2. 2.Res. Bldg. 1, Room 2000, 4635 Second Avenue, Sacramento, CA 95817, USA e-mail: Tel.: +1-916-734-3311, Fax: +1-916-734-5750US