Review Article

Pediatric Nephrology

, Volume 14, Issue 7, pp 572-578

Effects of IGFBP-2 overexpression in vitro and in vivo

  • E. WolfAffiliated withInstitute of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Feodor-Lynen-Str. 25, 81377 Munich, Germany e-mail: ewolf@lmb.uni-muenchen.de Tel.: +49-89-2180-6800, Fax: +49-89-2180-6849
  • , H. LahmAffiliated withInstitute of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Feodor-Lynen-Str. 25, 81377 Munich, Germany e-mail: ewolf@lmb.uni-muenchen.de Tel.: +49-89-2180-6800, Fax: +49-89-2180-6849
  • , M. WuAffiliated withInstitute of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Feodor-Lynen-Str. 25, 81377 Munich, Germany e-mail: ewolf@lmb.uni-muenchen.de Tel.: +49-89-2180-6800, Fax: +49-89-2180-6849
  • , R. WankeAffiliated withInstitute of Veterinary Pathology, Ludwig-Maximilian University, Munich, Germany
  • , A. HoeflichAffiliated withInstitute of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Feodor-Lynen-Str. 25, 81377 Munich, Germany e-mail: ewolf@lmb.uni-muenchen.de Tel.: +49-89-2180-6800, Fax: +49-89-2180-6849

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Abstract 

Insulin-like growth factor-binding proteins (IGFBPs) are important modulators of IGF actions and may have both stimulatory and inhibitory effects. Expression of IGFBP-2 is increased after fasting and in a variety of pathological conditions. However, the specific role of IGFBP-2 in growth physiology remains to be determined. In this review, we summarize data from in vitro and in vivo models suggesting that IGFBP-2 has mainly inhibitory effects on IGF actions. Since the growth hormone (GH)/IGF system is involved in a number of pathological alterations of the kidney and these changes may – at least in part – be due to increased IGF-I, local overexpression of inhibitory IGFBP-2 in the kidney might prevent IGF-I-induced lesions. This hypothesis will be tested by crossing GH transgenic mice, a common model of glomerulosclerosis, with transgenic mice characterized by systemic and renal overexpression of IGFBP-2.

Key words IGF-I IGFBP-2 Transfected cells Transgenic animals Glomerulosclerosis