Pediatric Nephrology

, Volume 29, Issue 9, pp 1553–1560

Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis

  • Yutaka Harita
  • Kiyonobu Ishizuka
  • Atsushi Tanego
  • Noriko Sugawara
  • Hiroko Chikamoto
  • Yuko Akioka
  • Haruko Tsurumi
  • Kenichiro Miura
  • Yoshimitsu Gotoh
  • Makoto Tsujita
  • Takayuki Yamamoto
  • Keiji Horike
  • Asami Takeda
  • Akira Oka
  • Takashi Igarashi
  • Motoshi Hattori
Original Article

DOI: 10.1007/s00467-014-2808-5

Cite this article as:
Harita, Y., Ishizuka, K., Tanego, A. et al. Pediatr Nephrol (2014) 29: 1553. doi:10.1007/s00467-014-2808-5

Abstract

Background

Circulating factor(s) has been thought to be the underlying cause of focal segmental glomerulosclerosis (FSGS), and recent studies foster this idea by demonstrating increased soluble urokinase receptor (suPAR) levels in the serum of FSGS patients.

Methods

To explore the possible contribution of suPAR in FSGS pathogenesis, we analyzed serum suPAR levels in 17 patients with FSGS and compared them with those in patients with steroid-sensitive nephrotic syndrome, chronic glomerulonephritis, or non-glomerular kidney diseases.

Results

Serum suPAR levels in patients with FSGS were higher than those in patients with steroid-sensitive nephrotic syndrome or chronic glomerulonephritis, but not higher than those in patients with non-glomerular kidney diseases. suPAR levels negatively correlate with estimated glomerular filtration rate and were decreased after renal transplantation in patients with FSGS as well as in those with non-glomerular kidney diseases. Furthermore, 6 FSGS patients with post-transplant recurrence demonstrated that suPAR levels were not high during the recurrence.

Conclusions

Based on our results, elevated suPAR levels in FSGS patients were attributed mainly to decreased glomerular filtration. These data warrant further analysis for involvement of possible circulating factor(s) in FSGS pathogenesis.

Keywords

Soluble urokinase receptorFocal segmental glomerulosclerosisPost-transplant recurrence

Copyright information

© IPNA 2014

Authors and Affiliations

  • Yutaka Harita
    • 1
  • Kiyonobu Ishizuka
    • 2
  • Atsushi Tanego
    • 3
  • Noriko Sugawara
    • 2
  • Hiroko Chikamoto
    • 2
  • Yuko Akioka
    • 2
  • Haruko Tsurumi
    • 1
  • Kenichiro Miura
    • 1
  • Yoshimitsu Gotoh
    • 4
  • Makoto Tsujita
    • 5
  • Takayuki Yamamoto
    • 5
  • Keiji Horike
    • 5
  • Asami Takeda
    • 5
  • Akira Oka
    • 1
  • Takashi Igarashi
    • 1
  • Motoshi Hattori
    • 2
  1. 1.Department of Pediatrics, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Pediatric NephrologyTokyo Women’s Medical UniversityTokyoJapan
  3. 3.Division of Biochemistry, School of Pharmaceutical SciencesKitasato UniversityTokyoJapan
  4. 4.Department of Pediatric NephrologyJapanese Red Cross Nagoya Daini HospitalNagoyaJapan
  5. 5.Kidney Disease CenterJapanese Red Cross Nagoya Daini HospitalNagoyaJapan