Review

Pediatric Nephrology

, Volume 30, Issue 5, pp 713-725

Proteomic urinary biomarker approach in renal disease: from discovery to implementation

  • Joost P. SchanstraAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic DiseaseUniversité Toulouse III Paul-SabatierMosaiques Diagnostics & Therapeutics
  • , Harald MischakAffiliated withMosaiques Diagnostics & TherapeuticsBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, Faculty of Medical, Veterinary and Life Sciences, University of Glasgow Email author 

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Abstract

Biomarkers hold the promise of significantly improving health care by enabling prognosis and diagnosis with improved accuracy, and at earlier points in time. Previous results have indicated that single biomarkers are not suitable to describe complex diseases such as kidney disease. Here we provide an update on the progress of urinary proteomics-based studies and strategies to develop biomarker-based classifiers that tolerate instability and inconsistency of individual biomarkers. The examples focus on two major fields in nephrology: chronic kidney disease in the adult population and obstructive nephropathies in the pediatric population. When employed adequately, urinary proteomics demonstrates a clear value in kidney disease, indicating that the current status quo ruling for decades now could be changed by applying modern “omics” approaches. However, while research is able to deliver these useful tools for patient management, the issues associated with implementation are not yet solved. Active engagement of the relevant clinical professional societies, as well as patient’s organizations, might help to implement these omics approaches that have shown a clear benefit for the patient.

Keywords

Clinical proteomics Biomarker panels Chronic kidney disease Obstructive nephropathy Urine Patient benefit Disease progression