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Desmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study

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Abstract

Background

The aim of this study was to compare the efficacy of combination therapy with desmopressin and an anticholinergic to desmopressin monotherapy for the first-line treatment of children with primary monosymptomatic nocturnal enuresis (PMNE).

Methods

A total of 98 children with PMNE (male:female 71:27) aged 5–16 (mean age 7.18 ± 1.8) years were retrospectively analyzed. The patients were divided into two groups: the monotherapy group (n = 49) was given oral desmopressin alone, and the combination therapy group (n = 49) was given desmopressin plus an anticholinergic (propiverine 10 mg) as a first-line treatment. The two groups were matched according to the following criteria: age, gender, and baseline frequency of nocturnal enuresis. The efficacy was evaluated by International Children’s Continence Society criteria at 1 and 3 months after treatment initiation.

Results

The combination therapy group showed a higher rate of complete response than the monotherapy group (20.4 vs. 6.1 % at 1 month of treatment; 46.9 vs. 22.4 % at 3 months of treatment). In terms of success (response and complete response), there was a significant difference between the two groups after 3 months of treatment (P = 0.002).

Conclusions

Our results indicate that combination therapy with desmopressin plus an anticholinergic is quicker and more effective than desmopressin monotherapy in reducing PMNE.

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Funding

This study was supported by Samsung Medical Center grant (CRS 1110631).

Declaration of interest

None.

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Authors and Affiliations

  1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea

    Se Jin Park & Ki Soo Pai

  2. Department of Pediatrics, Uvis Hospital, Incheon, Republic of Korea

    Ji Min Park

  3. Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Republic of Korea

    Tae Sun Ha

  4. Department of Urology, Pusan National University Yangsan Hospital, Pusan, Republic of Korea

    Sang Don Lee

  5. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea

    Minki Baek

Authors
  1. Se Jin Park
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  2. Ji Min Park
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  3. Ki Soo Pai
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  4. Tae Sun Ha
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  5. Sang Don Lee
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Consortia

The Korean Children’s Continence and Enuresis Society

Corresponding author

Correspondence to Minki Baek.

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Park, S.J., Park, J.M., Pai, K.S. et al. Desmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study. Pediatr Nephrol 29, 1195–1200 (2014). https://doi.org/10.1007/s00467-014-2751-5

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  • DOI: https://doi.org/10.1007/s00467-014-2751-5

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