Pediatric Nephrology

, Volume 29, Issue 4, pp 705–710

Priming the renal progenitor cell

  • Diana M. Iglesias
  • Murielle M. Akpa
  • Paul Goodyer
Review

DOI: 10.1007/s00467-013-2685-3

Cite this article as:
Iglesias, D.M., Akpa, M.M. & Goodyer, P. Pediatr Nephrol (2014) 29: 705. doi:10.1007/s00467-013-2685-3

Abstract

The mammalian kidney arises from OSR1(+) progenitor cells in the intermediate mesoderm. However, these cells must acquire unique properties before they can respond to inductive signals that launch the differentiation program. Recent data indicate that the transcription factor, WT1, plays a master role in this transition. Interestingly, some of these embryonic nephron progenitor cells are retained in the adult organ where they may participate in tissue regeneration after acute kidney injury. A better understanding of the biology of these cells may one day allow progenitor cell-based therapeutic strategies to help regenerate damaged adult nephrons.

Keywords

Renal progenitor cellsWT1OSR1Intermediate mesodermCell therapyEpigeneticsDifferentiationAcute tubular necrosis

Copyright information

© IPNA 2014

Authors and Affiliations

  • Diana M. Iglesias
    • 1
  • Murielle M. Akpa
    • 1
  • Paul Goodyer
    • 1
  1. 1.McGill UniversityMontreal Children’s Hospital Research InstituteMontréalCanada