Pediatric Nephrology

, Volume 29, Issue 8, pp 1337–1347

Solid organ transplantation following end-organ failure in recipients of hematopoietic stem cell transplantation in children

Educational Review

DOI: 10.1007/s00467-013-2587-4

Cite this article as:
Upadhyay, K. & Fine, R.N. Pediatr Nephrol (2014) 29: 1337. doi:10.1007/s00467-013-2587-4

Abstract

Hematopoietic stem cell transplantation (HSCT) is an accepted treatment modality for various malignant and non-malignant disorders of the lympho-hematopoietic system. Patient survival rate has increased significantly with the use of this procedure. However, with the increase in disease-free patient survival rates, complications including various organ toxicities are also common. Kidney, liver, lung, heart, and skin are among those solid organs that are commonly affected and frequently lead to organ dysfunction and eventually end-organ disease. Conservative measures may or may not be successful in managing the organ failure in these patients. Solid organ transplantation has been shown to be promising in those patients who fail conservative management. This review will summarize the causes of solid organ (kidney, liver, and lung) dysfunction and the available data on transplantation of these solid organs in post-HSCT recipients.

Keywords

Hematopoietic stem cell transplantationChildrenKidneyLiverLungEnd-organ dysfunction

Copyright information

© IPNA 2013

Authors and Affiliations

  1. 1.Division of Pediatric Nephrology, Department of Pediatrics, Stony Brook Long Island Children’s HospitalState University of New York at Stony BrookStony BrookUSA