Pediatric Nephrology

, Volume 28, Issue 7, pp 1145–1149

Limited value of routine microalbuminuria assessment in multi-ethnic obese children


    • Department of PediatricsSlotervaart Hospital
  • Mariska van Vliet
    • Department of Internal MedicineSlotervaart Hospital
  • Ines A. von Rosenstiel
    • Department of PediatricsSlotervaart Hospital
  • Jos H. Beijnen
    • Department of Pharmacy & PharmacologySlotervaart Hospital
  • Michaela Diamant
    • Department of Endocrinology/Diabetes CenterVU University Medical Center (VUmc)
Brief Report

DOI: 10.1007/s00467-013-2451-6

Cite this article as:
Radhakishun, N.N.E., van Vliet, M., von Rosenstiel, I.A. et al. Pediatr Nephrol (2013) 28: 1145. doi:10.1007/s00467-013-2451-6



To determine the prevalence of microalbuminuria and its association with cardiometabolic risk factors in a multi-ethnic cohort of overweight and obese children.


A retrospective analysis of prospectively collected data was performed using data from 408 overweight and obese children (age 3–19 years). In addition to administering an oral glucose tolerance test, we measured anthropometric variables, plasma lipid levels, alanine aminotransferase and the urinary albumin/creatinine ratio (ACR). Microalbuminuria was defined as an ACR of between 2.5 and 25 mg/mmol in boys and 3.5 and 25 mg/mmol in girls. In total, only 11 (2.7 %) of the children analyzed presented with microalbuminuria, with no differences between ethnic groups, sex or in the prevalence of hypertension compared to the children with normoalbuminuria. After adjustment for confounders, the body mass index Z-score tended to be different between the group with microalbuminuria versus that without (3.6 vs. 3.2, respectively; P = 0.054). ACR was not associated with hypertension, impaired glucose tolerance, high triglycerides or low high-density lipoprotein-cholesterol.


In a large multi-ethnic cohort of overweight and obese children, we found a low prevalence of microalbuminuria (11 children, 2.7 %), and in this small number of individuals, we found no association with any of the cardiometabolic risk factors assessed. Therefore, our data do not support the routine measurement of microalbuminuria in asymptomatic overweight and obese children and adolescents.


Albumin/creatinine ratioCardiometabolic risk factorsBody mass indexMetabolic syndromeAlbuminuriaPrevalence

Copyright information

© IPNA 2013