Pediatric Nephrology

, Volume 28, Issue 6, pp 979–981

Native kidney BK virus nephropathy associated with acute lymphocytic leukemia

Brief Report

DOI: 10.1007/s00467-013-2438-3

Cite this article as:
Filler, G., Licht, C. & Haig, A. Pediatr Nephrol (2013) 28: 979. doi:10.1007/s00467-013-2438-3

Abstract

Background

Polyoma BK virus nephropathy is a common complication after renal transplantation and is rarely seen in non-renal transplant recipients. There are only a couple of case reports of BK virus nephropathy in native kidneys in non-transplant patients, including a recent report of a 73-year-old patient with chronic lymphatic leukemia. A variety of treatment options, including leflunomide and cidofovir, were reported in these patients.

Case diagnosis/treatment

Here we report the case of a 10-year-old boy with acute lymphatic leukemia who presented with non-oliguric hypertensive acute kidney injury at the 12th maintenance cycle of his chemotherapy. The workup supported the clear diagnosis of BK virus nephropathy with tubulointerstitial changes, and the patient responded favorably to intravenous immunoglobulin therapy.

Conclusions

Pediatric nephrologists need to consider BK virus nephropathy as a differential diagnosis of acute kidney injury in immunocompromised non-transplant patients.

Keywords

Polyomavirus BK virusNephropathyRenal transplantationAcute lymphocytic leukemia

Copyright information

© IPNA 2013

Authors and Affiliations

  1. 1.Department of Pathology & Laboratory MedicineLondon Health Science Centre—University of Western OntarioLondonCanada
  2. 2.Department of Pediatrics, Division of NephrologyChildren’s Hospital, London Health Science Centre—University of Western OntarioLondonCanada
  3. 3.Division of Nephrology, Department of PediatricsThe Hospital for Sick ChildrenTorontoCanada