Pediatric Nephrology

, Volume 28, Issue 8, pp 1183–1193

How benign is hematuria? Using genetics to predict prognosis

Authors

    • University College London—Centre for Nephrology
Review

DOI: 10.1007/s00467-012-2399-y

Cite this article as:
Gale, D.P. Pediatr Nephrol (2013) 28: 1183. doi:10.1007/s00467-012-2399-y

Abstract

Hematuria is a common presenting feature of glomerular disease and is sometimes associated with kidney failure later in life. Where isolated microscopic hematuria occurs in children and young adults, an underlying monogenic disorder, such as Alport syndrome or thin basement membrane nephropathy, is frequently responsible. In this review, these and other diseases, which often present with isolated microscopic hematuria, including hereditary angiopathy, nephropathy, aneurysms, and muscle cramps (HANAC) syndrome, IgA nephropathy, and CFHR5 nephropathy, are discussed together with the associated molecular pathology, clinical features, and prognosis. Genetic testing for these conditions used in clinical practice can provide important diagnostic and prognostic information that is relevant to the patient and their family, particularly when kidney transplantation is considered.

Keywords

TBMNGlomerular basement membraneAlportHANACCFHR5MYH9Glomerulonephritis

Copyright information

© IPNA 2013