Do vitamin D plasma levels impact vaccine response in children with idiopathic nephrotic syndrome?
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We have previously shown that pediatric patients with nephrotic syndrome have a high serological response after 23-valent pneumococcal vaccination . The response was not different in those who received the vaccine in remission without steroids and those who received the vaccine while having nephrotic proteinuria and high dose steroids. However, the anti pneumococcal antibody response 1 month post-vaccination ranged from a 2- to 50-fold increase. This heterogeneous response was not explained by patient age, plasma albumin levels, or concomitant immunosuppressive treatment .
Vitamin D (Vit D) analyses were performed on serum samples taken at the time of vaccination and kept at −20 °C. We analyzed 1,25-(OH)2-D3 and 25-(OH)-D3 plasma levels in pediatric patients in whom pneumococcal antibodies were available at baseline, 1 month, 3 months, and 6 months post-vaccine. Correlation of Vit D levels with anti-pneumococcal antibody levels was studied using Pearson correlation.
- Ulinski T, Leroy S, Dubrel M, Danon S, Bensman A (2008) High serological response to pneumococcal vaccine in nephrotic children at disease onset on high-dose prednisone. Pediatr Nephrol 23:1107–1113 CrossRef
- Lalor MK, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM (2011) BCG vaccination: a role for vitamin D? PLoS One 6:e16709 CrossRef
- Wu HM, Tang JL, Cao L, Sha ZH, Li Y (2012) Interventions for preventing infection in nephrotic syndrome. Cochrane Database Syst Rev 4:CD003964
- Froicu M, Weaver V, Wynn TA, McDowell MA, Welsh JE, Cantorna MT (2003) A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol 17:2386–2392 CrossRef
- Zitt E, Sprenger-Mahr H, Knoll F, Neyer U, Lhotta K (2012) Vitamin D deficiency is associated with poor response to active hepatitis B immunisation in patients with chronic kidney disease. Vaccine 30:931–935 CrossRef
- Do vitamin D plasma levels impact vaccine response in children with idiopathic nephrotic syndrome?
Volume 27, Issue 11 , pp 2161-2162
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- 1. Service de Néphrologie et Dialyses Pédiatrique, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Avenue du Docteur Netter, 75012, Paris, France
- 2. Université Pierre et Marie Curie (UMPC), Paris 6, Paris, France
- 3. Laboratoire d’explorations fonctionnelles, Hôpital Necker Enfants Malades, APHP, Paris, France