, Volume 27, Issue 11, pp 2161-2162
Date: 16 Aug 2012

Do vitamin D plasma levels impact vaccine response in children with idiopathic nephrotic syndrome?

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Dear Sirs,

We have previously shown that pediatric patients with nephrotic syndrome have a high serological response after 23-valent pneumococcal vaccination [1]. The response was not different in those who received the vaccine in remission without steroids and those who received the vaccine while having nephrotic proteinuria and high dose steroids. However, the anti pneumococcal antibody response 1 month post-vaccination ranged from a 2- to 50-fold increase. This heterogeneous response was not explained by patient age, plasma albumin levels, or concomitant immunosuppressive treatment [1].

Vitamin D (Vit D) analyses were performed on serum samples taken at the time of vaccination and kept at −20 °C. We analyzed 1,25-(OH)2-D3 and 25-(OH)-D3 plasma levels in pediatric patients in whom pneumococcal antibodies were available at baseline, 1 month, 3 months, and 6 months post-vaccine. Correlation of Vit D levels with anti-pneumococcal antibody levels was studied using Pearson correlation.