, Volume 27, Issue 11, pp 2001-2005
Date: 03 Jun 2012

Can dialysis modality influence cardiovascular outcome?

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Introduction

Children with chronic kidney disease (CKD), particularly those on long-term dialysis, have a significant burden of cardiovascular disease (CVD). The mortality of children on dialysis is 700-fold higher than that of their healthy peers [1], and CVD is the most common cause of death [24]. Amongst children with CKD, both cardiac [5] and vascular damage and calcification [6] are present from the pre-dialysis CKD stages, and these increase in prevalence and severity on dialysis [6]. Importantly, all paediatric and adult studies conducted to date have shown that CVD progression with deteriorating cardiac function and progressive vascular calcification is associated with a long dialysis vintage [1, 3, 611] on both haemodialysis (HD) and peritoneal dialysis (PD).

Cardiovascular mortality among patients on PD and HD

Adult studies have reported variable cardiovascular outcomes among patients on PD and HD. In a recent study among adult dialysis recipients, mortality was lower in incid ...