Pediatric Nephrology

, Volume 27, Issue 6, pp 891–900

Integrins in renal development

Authors

  • Sijo Mathew
    • Department of Medicine (Division of Nephrology)Vanderbilt University Medical Center
  • Xiwu Chen
    • Department of Medicine (Division of Nephrology)Vanderbilt University Medical Center
    • Department of Medicine (Division of Nephrology)Vanderbilt University Medical Center
    • Department of Cancer BiologyVanderbilt University Medical Center
    • Department of MedicineVeterans Administration Hospital
    • Division of Nephrology and HypertensionVanderbilt University
    • Department of Medicine (Division of Nephrology)Vanderbilt University Medical Center
    • Department of Cancer BiologyVanderbilt University Medical Center
    • Department of Cell and Developmental BiologyVanderbilt University Medical Center
    • Department of MedicineVeterans Administration Hospital
    • Division of Nephrology and HypertensionVanderbilt University
Review

DOI: 10.1007/s00467-011-1890-1

Cite this article as:
Mathew, S., Chen, X., Pozzi, A. et al. Pediatr Nephrol (2012) 27: 891. doi:10.1007/s00467-011-1890-1

Abstract

The kidney develops from direct interactions between the ureteric bud and the metanephric mesenchyme. The ureteric bud gives rise to the collecting system and the metanephric mesenchyme to the nephrons. The complex process of renal development which occurs between these embryologically distinct structures is mediated by numerous factors, including the communication of cells with their surrounding extracellular matrix. Integrins are the principal cellular receptors for extracellular matrix proteins, and they play a role in organ and tissue development. In this review we focus on how integrins regulate renal development.

Keywords

Extracellular matrixBasement membraneKidneyMorphogenesis

Copyright information

© IPNA 2011