Pediatric Nephrology

, 26:979

Primary antiphospholipid syndrome presenting as renal vein thrombosis and membranous nephropathy

  • Swasti Chaturvedi
  • Leonardo Brandao
  • Denis Geary
  • Christoph Licht
Brief Report

DOI: 10.1007/s00467-011-1787-z

Cite this article as:
Chaturvedi, S., Brandao, L., Geary, D. et al. Pediatr Nephrol (2011) 26: 979. doi:10.1007/s00467-011-1787-z
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Abstract

Antiphospholipid syndrome is a multisystem auto-immune disorder characterized by thrombotic events and the presence of circulating antiphospholipid antibodies. Large vessel involvement in the form of thrombosis/stenosis and thrombotic microangiopathy is a commonly described renal finding. However, non-thrombotic glomerulopathies are increasingly being recognized in patients with antiphospholipid syndrome. We report a rare occurrence of both renal vein thrombosis and membranous nephropathy in a previously healthy adolescent male. Investigations revealed persistently positive antiphospholipid antibodies in the absence of an underlying systemic autoimmune disorder or malignancy. Our patient responded favourably to anti-proteinuric therapy and anticoagulation with complete resolution of proteinuria and a nearly occlusive thrombus.

Keywords

Antiphospholipid syndromeNephrotic syndromeMembranous nephropathyDeep venous thrombosis

Copyright information

© IPNA 2011

Authors and Affiliations

  • Swasti Chaturvedi
    • 1
  • Leonardo Brandao
    • 2
    • 3
  • Denis Geary
    • 1
    • 3
  • Christoph Licht
    • 1
    • 3
  1. 1.Division of NephrologyThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Division of HaematologyThe Hospital for Sick ChildrenTorontoCanada
  3. 3.University of TorontoTorontoCanada