Pediatric Nephrology

, Volume 27, Issue 2, pp 183–193

The origin of interstitial myofibroblasts in chronic kidney disease

  • Ivica Grgic
  • Jeremy S. Duffield
  • Benjamin D. Humphreys
Review

DOI: 10.1007/s00467-011-1772-6

Cite this article as:
Grgic, I., Duffield, J.S. & Humphreys, B.D. Pediatr Nephrol (2012) 27: 183. doi:10.1007/s00467-011-1772-6

Abstract

Chronic kidney diseases (CKD), independent of their primary cause, lead to progressive, irreversible loss of functional renal parenchyma. Renal pathology in CKD is characterized by tubulointerstitial fibrosis with excessive matrix deposition produced by myofibroblasts. Because blocking the formation of these scar-forming cells represents a logical therapeutic target for patients with progressive fibrotic kidney disease, the origin of renal myofibroblasts is a subject of intense investigation. Although the traditional view holds that resident fibroblasts are the myofibroblast precursor, for the last 10 years, injured epithelial cells have been thought to directly contribute to the myofibroblast pool by the process of epithelial-to-mesenchymal transition (EMT). The recent application of genetic fate mapping techniques in mouse fibrosis models has provided new insights into the cell hierarchies in fibrotic kidney disease and results cast doubt on the concept that EMT is a source of myofibroblast recruitment in vivo, but rather point to the resident pericyte/perivascular fibroblast as the myofibroblast progenitor pool. This review will highlight recent findings arguing against EMT as a direct contributor to the kidney myofibroblast population and review the use of genetic fate mapping to elucidate the cellular mechanisms of kidney homeostasis and disease.

Keywords

Fibrosis EMT Myofibroblast Chronic kidney disease Genetic fate mapping 

Copyright information

© IPNA 2011

Authors and Affiliations

  • Ivica Grgic
    • 1
    • 2
  • Jeremy S. Duffield
    • 3
  • Benjamin D. Humphreys
    • 1
    • 4
  1. 1.Renal DivisionBrigham and Women’s HospitalBostonUSA
  2. 2.Department of Internal Medicine and NephrologyPhilipps-UniversityMarburgGermany
  3. 3.Division of Nephrology & Institute for Stem Cell and Regenerative Medicine, Laboratory of Inflammation ResearchUniversity of WashingtonSeattleUSA
  4. 4.Harvard Stem Cell InstituteCambridgeUSA

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