Pediatric Nephrology

, Volume 26, Issue 5, pp 705–711

Fetal environment, epigenetics, and pediatric renal disease

Authors

  • Robert Woroniecki
    • Department of Pediatrics, NephrologyAlbert Einstein College of Medicine
  • Anil Bhanudas Gaikwad
    • Department of Medicine, Division of NephrologyAlbert Einstein College of Medicine
    • Department of Medicine, Division of NephrologyAlbert Einstein College of Medicine
    • Department of GeneticsAlbert Einstein College of Medicine
Educational Review

DOI: 10.1007/s00467-010-1714-8

Cite this article as:
Woroniecki, R., Gaikwad, A.B. & Susztak, K. Pediatr Nephrol (2011) 26: 705. doi:10.1007/s00467-010-1714-8

Abstract

The notion that some adult diseases may have their origins in utero has recently captured scientists’ attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.

Keywords

EpigeneticsIntrauterine environmentHistone modificationDNA methylation

Copyright information

© IPNA 2010